| Entrez gene ID | | 7293 |
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| Official gene symbol | | TNFRSF4 |
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| Full name | | tumor necrosis factor receptor superfamily, member 4 |
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| Aliases | | ,ACT35,CD134,OX40,TXGP1L, |
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| Gene summary | | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq] |
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| Location | | Chromosome: 1 Locus: 1p36 |
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| Gene position | | 1149512 - 1146706 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 2807 bp |
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| Gene sequence |
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| OMIM ID | | 600315 |
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