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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UBB (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7314 Official gene symbol UBB Full name ubiquitin B Aliases ,FLJ25987,MGC8385,RPS27A,UBA52,UBC, Gene summary This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. [provided by RefSeq] Location Chromosome: 17   Locus: 17p12-p11.2 Gene position 16284367 - 16286054  Map Viewer Gene orientation plus Gene size 1688 bp Gene sequence >UBB:15887741..15889428:Length=1688 CACTCGTTGCATAAATTTGCGCTCCGCCAGCCCGGAGCATTTAGGGGCGGTTGGCTTTGT TGGGTGAGCTTGTTTGTGTCCCTGTGGGTGGACGTGGTTGGTGATTGGCAGGATCCTGGT ATCCGCTAACAGGTACTGGCCCGCAGCCGTAACGACCTTGGGGGGGTGTGAGAGGGGGGA ATGGGTGAGGTCAAGGTGGAGGCTTCTTGGGGTTGGGTGGGCCGCTGAGGGGAGGGCGTG GGGGAGGGGAGGGCGAGGTGACGCGGCGCTGGGCCTTTCCGGGACAGTGGGCCTTGTTGA CCTGAGGGGGGCGAGGGCGGTTGGCGCGCGCGCGCGTTGACGGAAACTAACGGACGCCTA ACCGATCGGCGATTCTGTCGAGTTTACTTCGCGGGGAAGGCGGAAAAGAGGTAGTTTGTG TGGTTTCTGGAAGCCTTTACTTTGGAATCCCAGTGTGAGAAAGGTGCCCCTTCTTGTGTT TCAATGGGATTTTTATTTCGCGAGTCTTGTGGGTTTGGTTTTGTTTTCAGTTTGCCTAAC ACCGTGCTTAGGTTTGAGGCAGATTGGAGTTCGGTCGGGGGAGTTTGAATATCCGGAACA GTTAGTGGGGAAAGCTGTGGACGCTTGGTAAGAGAGCGCTCTGGATTTTCCGCTGTTGAC GTTGAAACCTTGAATGACGAATTTCGTATTAAGTGACTTAGCCTTGTAAAATTGAGGGGA GGCTTGCGGAATATTAACGTATTTAAGGCATTTTGAAGGAATAGTTGCTAATTTTGAAGA ATATTAGGTGTAAAAGCAAGAAATACAATGATCCTGAGGTGACACGCTTATGTTTTACTT TTAAACTAGGTCAAAATGCAGATCTTCGTGAAAACCCTTACCGGCAAGACCATCACCCTT GAGGTGGAGCCCAGTGACACCATCGAAAATGTGAAGGCCAAGATCCAGGATAAGGAAGGC ATTCCCCCCGACCAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGTACT CTTTCTGACTACAACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGT GGTATGCAGATCTTCGTGAAGACCCTGACCGGCAAGACCATCACCCTGGAAGTGGAGCCC AGTGACACCATCGAAAATGTGAAGGCCAAGATCCAGGATAAAGAAGGCATCCCTCCCGAC CAGCAGAGGCTCATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTAC AACATCCAGAAGGAGTCGACCCTGCACCTGGTCCTGCGTCTGAGAGGTGGTATGCAGATC TTCGTGAAGACCCTGACCGGCAAGACCATCACTCTGGAGGTGGAGCCCAGTGACACCATC GAAAATGTGAAGGCCAAGATCCAAGATAAAGAAGGCATCCCCCCCGACCAGCAGAGGCTC ATCTTTGCAGGCAAGCAGCTGGAAGATGGCCGCACTCTTTCTGACTACAACATCCAGAAA GAGTCGACCCTGCACCTGGTCCTGCGCCTGAGGGGTGGCTGTTAATTCTTCAGTCATGGC ATTCGCAGTGCCCAGTGATGGCATTACTCTGCACTATAGCCATTTGCCCCAACTTAAGTT TAGAAATTACAAGTTTCAGTAATAGCTGAACCTGTTCAAAATGTTAATAAAGGTTTCGTT GCATGGTA OMIM ID 191339