Entrez gene ID | | 7318 |
Official gene symbol | | UBA7 |
Full name | | ubiquitin-like modifier activating enzyme 7 |
Aliases | | ,D8,MGC12713,UBA1B,UBE1L,UBE2, |
Gene summary | | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p21 |
Gene position | | 49851391 - 49842638 Map Viewer |
Gene orientation | | minus |
Gene size | | 8754 bp |
Gene sequence |
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OMIM ID | | 191325 |
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