Entrez gene ID | | 7323 |
Official gene symbol | | UBE2D3 |
Full name | | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) |
Aliases | | ,E2(17)KB3,MGC43926,MGC5416,UBC4/5,UBCH5C, |
Gene summary | | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q24 |
Gene position | | 103790032 - 103717133 Map Viewer |
Gene orientation | | minus |
Gene size | | 72900 bp |
Gene sequence |
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OMIM ID | | 602963 |
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