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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UCP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7350 Official gene symbol UCP1 Full name uncoupling protein 1 (mitochondrial, proton carrier) Aliases ,SLC25A7,UCP, Gene summary Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq] Location Chromosome: 4   Locus: 4q28-q31 Gene position 141489959 - 141481050  Map Viewer Gene orientation minus Gene size 8910 bp Gene sequence >UCP1:complement(66028771..66037680):Length=8910 AGAGCAAGGGAAAGGAACTTCCTCCACCTTCGGGGCTGGAGCCCTTTTCCTCTGCATCTC CAGTCTCTGAGTGAAGATGGGGGGCCTGACAGCCTCGGACGTACACCCGACCCTGGGGGT CCAGCTCTTCTCAGCTGGAATAGCGGCGTGCTTGGCGGACGTGATCACCTTCCCGCTGGA CACGGCCAAAGTCCGGCTCCAGGTAGCTAGGCAGAGGGGTAAGACAAGGGGTCTCAGGAC AGAGGGGACGCTGTTGCGTGCATTCCATTTATTCTCTGCTTTGGTGTAACCACTGTTTCT AGGTAGGGTAGGTGACCTTCCAAAGCAGTCTGGCCTTGTCCCAGGGCTGGTGCTTTAGGA TGGGAAACTGGAACTTTTTCTGGGATTAGCTGAAGAACCACCAGGGCCACAGAGAATGGG TTGACCATGACTACTACCAAATTCTCCCAAAATTTAGGGTGCACTTAGTATTTTAAGAGC TGAGAATATTGGCCTCTCCTGAGTTTACTAGTCAGGTGCTTTTTCCTTTCTTTGATTCTT CGGGGGTTCTGTCCTATCCTACTGCCCTAGGGGTTCTGGAGAGTTCCTGGGGAGGGGGAT ATTCAAAATGTGCATTGTAGCCAGCCTCCCTCCATCTGCGCGTGAGCGAACACACACACA CACACACACACACACACACACACACACACACACACACGGTAGAGGGAGGTGGATGGAAGA GGAATGTTGCTGAGAAAAGAAACGGAAAATAGGAACACAGGGGGAAATCTTGGCTTAAGA GTGAACTCAATTTCGCTCCCTTCTGTTCTGCACCTTTCTTATTTCCAGGTCCAAGGTGAA TGCCCGACGTCCAGTGTTATTAGGTATAAAGGTGTCCTGGGAACAATCACCGCTGTGGTA AAAACAGAAGGGCGGATGAAACTCTACAGCGGGCTGCCTGCGGGGCTTCAGCGGCAAATC AGCTCCGCCTCTCTCAGGATCGGCCTCTACGACACGGTCCAGGAGTTCCTCACCGCAGGG AAAGAAAGTAAGCCGTGAGCGTTCCTGGGAGGGGCAGAAAAGCCTTGGGCTCCGCTCTGT TCCAAAAAGTGTAACACACAGAGGAGTGGTTTTCATAACAAATTGGCGAGAAAACATTCA TATTTGAACTCTCCCTTCCCCAAACATTAGCTCATTGTTCATAGAAAAAAGTATGCAAAA TCGATTTTTTAGATGCAGATATATACTTGTAAAGGTCACCCAGTCATGGAAGTTTTGTGC CCAGTTTGGATCTCCATCTGGAGAATATGGGTGGGCTACAGAAAAATGTTTAACTTAAAG TTCTCCAAAGAGGGAAGTATATCAGAAACATCTATGGAGCTTGTCAGAAATCCAAACGAG GACTACCATGGTCCTCTGAGTCTGAATCCTCAGGCTAGAGACCAGAGTGTCTTTCCACAA GCTTCCCTCATCATTTGTGTATGCAACAAAGTTCAAAGCCTTCTGTTTGAAGCAAAGAAA GCCAGACTTTGTGAAGAGAGTTGAAAGGACAGGAAAAGACATATTTCCTCTTAAGAGGTT CCTCATCAGGTCCAGGAAAGACCAGAGCAGAAAAAGTGGACGAATGCTGCAGGGAGTTTG TTTAGGGGAAAAAGAAAAGGAAACATATTTCCTGAGTGCCAGTGCACTCTAAGAATTCCT GTCACTTTAGGTAGCATTTATTTGAGGGCTTAACTATGAACCAGACATTGTTCTAAGTGC TTCAGATACATTATAACTGGAAGGGTATTAGTACCATTATCCCTTGGCAGATGGGAAAAC TGAACACAGAGCAGATTCATCACTTGCCCAAGGTCACACAGCTGGGAGGGGGCAGAGCCA GGGTTCAAACCCAGGCAGTCTGGCCTCGGACTCCAGGCTCCTAACCCTGTTCTCTACTGC CTTCTGCACTTCTCATATGATTCTGCCCATCATTCAAACCGCACAACACTGCTGTGAGTA AAAAGTGTTAGCCGAATATCAGGGTAGTTAAGTAACATGCACAAAATCACACAGCTAATC AACATCAGAGGCACTTTCATGTGGAGTAGACAAGCCAGAGAGAAGATGTGCTGATGGCAC AATGAATACATTAAGTGAAATCCACCTTGTAGATTTCATCATTTCTGCTGTGAGTAACCT TCAATACTATAATTTTATGGGATAATTTATAAATGTTGTCTATACAAATATATAAGTTAT ACTTATCCACACAAGTACTTTCAAAGTGAAGATAAAGTCTGGATGTTACTAGATCAAAAC TGCATTTTTTTATTTATAGATGTAGCAAGAGAGGAAACACAAAGGAGGTAAAGCTGCCCG TTCAGGTGGTTTTCTTCACAGATTGACTGTTCTACCAATTGTTGTGGACTTTGGGCACCA AATTAATAGGATATATGTTGGCAGTGTTCTATGTTATATAGATTCAGTTTATTTAGTAGG CTTTATTGAACTGCCATGTGCCAGTAACTATGTTAGATGTTTAGATGGCAGATGTGTCTC TAGACAGAGCTTACAGTTGAGAGTATGGGTTGTGTGGGGAGAAGTGAATAGATGACTATA TTCCATGATACATGCTGTATTACAATACAGTCCTACTTCACTTAACGATGGGGATACATT CTCAGAAATGAGTTAGGAGGCAAATTGGTTGTTGAATGAACATCACAGAGAGCACTTACA CAAACCTAGATGGCATAGCCACACCTAGGCTATATGGTATAATCTATTGCTCCTAGGCTA CAAACCTGTGCAGCATGTTGGTATTGAATACTACAGGCAATTGTTACATAAAGTTAAGTG TTTGTGTACCTAAAAATAGAAAAGGTAATGCATTACACTACAGTCTTATGGGGCTGGGAT GTCACTAGGTGATAGGAATTTTTCAGCTCTGTTCTAATCTTACGGGACCACCATCATGTA TGCAGCACATGACTAACTGTAATTACAAGATGGTGGCTATATTAAACAGAACTACTTAAG CTAGCCATGGAGGTATGGTCCGTGAGATTTTCCTGAAGAATTAACGTCTGGATCAATTCT GGAAGGGCCAGCAGGAGTACTCCAGGCAAAGGGGTGAGAAAGGAGCTTCCAAGTAGAGTG AAGGTCATGTGCAAAGACTCAGTGAGGAGTCGAGTGAACATAGCACAGGGAGGACATGTT GGTGAGGAAGGAGGGGTGAAGCCACAGAGACAGGAGGGAGCCAGATGACAGAAGGCCTTG CAGGCGGTGCTAAGGAGTTTGGATTTTATCCTTACAGTGGTGGGAAGTCATTGTAAAAAT ATTAAGCAAGGGAGTGGCATAAACAATTTACATTTTCAAAAGATCACTTTGGCAGCAGAT AGAGTATATATGTAAAAGGAGTAAGAAAGAGGTAAGTTAGAAAGCAAGAAATGATCAGGG TATGCCCTAAAACACTGGCAATAGGGAAAAAGAGATGTCAATCAGAAAGATTGAGAAAGT ATAATTGAATTGACTTGGTGAACAAATAGAAGTAAGGCATAAGGGACAGGTAGAAATATG AGATGACTTCCAAGTTTCTGTTTAAAGATACCCTTTATTGAGAGAGGATGTATAGAAGCT GTCTTAGGGGGAAGACAAGAAATTTGGTTTAGGCCATGTCAACAGGTAATGGCCAGTAGG CACATGATTCAGTTTATTTAGTGGGCTCCTTTTAGGAGAAAATCTGAGCCAGATTCCAGG AAGTCACAGCAGGGACTACCAATAGGGTCAAACAGCAGAGAGTGTGGAAAGGACTGAAAA GTGATCATTGTACATAACAAATAGAAGCTCACTGATTTTCTAGCAAAAACATCTTCAGCA GAGTAGCGTGGTATAAGCTATATTGTAGGGGACTGAGGAAGAAATGGGCTCTGAGAAGTA AAGACAAACAATATGTTTTGTAAATAAATTTCTTTTAGTTCTTAAAAAAAAAGCCTCTTT TCCAGCTTGATTGGGAAGTGAAGAGAGGGATTTGAAAGTTGGAGATTGGAGGATAGGATG AGTACATCAAGATACACTACGTTGTAGTGCAGTGCATTACAAATGTGAGCTAAAAGTGAA GGCATTTGTAATCATATGATATTGCTAATTAAAAGACAGCTGTCAGTCATATGCCCAGCT CCTGGTAAAGCATGATGAGAAGAGTACAATCATGGTAGTGATTTAAAAATTGCTGCCAGT TTTGTGGATTTTCTTTATGCTAGACAGTGTAAGCTCTTTATCAATATTATTTAACTCACA CAACTCTAAGAGGTAGATATTATTATCCCTTTTTGACAAATTAGGAAACAGAATTATAAT GACTGAGAAAGTCTCTGCTGAGTAAATGTTACTGAACCTTAATTTTATGTTTACTTAATG ATAGAAATGAATATTGGGCTTCAAGACTATTTGTACTTAATGAAATCTGTCTTGAGCAAC ATAAGCTATTTTTTTCAAAATTTTAAGACAAAAATCACTTTCTTCTCTCCTGTCTTCTTA TTTTTGTTCCCTTCACATGTTGTAGCCTAACACTACTTGATGGCCCATTTTGGTGCAGTT TGTCCACTGGGCTTCATCTAAGGCCACCAAGTCCCATAATTAACATGATCATTCGTGGGA GAAAGATCAAGCCTCATTGGTGATGGGTGCCTCCTCACAGTCGGATAATACTGAAAAGAG AGCTAAATGTGGGAAAGAACCAAGTTGAACACAGGAAAGAATCAGGCCACTGTGAAAATA AGCATTGTGTTTTCTTGTTCCTTGAAAGTCTTCATTTTTAAAAAATTTCAGACACCTGAA GTTTTCTAGCCTTACTCTGAGTTGACGCACATTTAGTACATGATCAACACATAAACAAGC ATTAGAGAAATAGAAAAGCTGTAAGAATACAAAAATATGGGCCAGGTGGGTGGCTCATAC CTGTAATCCTAGCACTTTGGGAGGCCGAGGCAGACGGATCACCTGAGGTCAGGAGTTCAA GACTAGCCTGGCCAATATAGTGAAACCCTGTCTCTACTAAAAATACAAAACTTAGCAGGC TGTGGTGGCACGTGCCTATAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATCTCTTG AACCCGGGAGGCGGAGATTGCAGTGAGCCAAGATCACACCACTGCACTCTAGCCTAGATA ACAGAGCAAGACTCCATCTCAAAAAAAAAAAAAATACAAAAATATGAACCACTGAAAATT AAAAAGACATGCATGCATTCTAGGTCTTTAATTTTTTTTCTTAATAATTTTTTTTCTCTC TGGATAGCAGCACCTAGTTTAGGAAGCAAGATTTTAGCTGGTCTAACGACTGGAGGAGTG GCAGTATTCATTGGGCAACCCACAGAGGTCGTGAAAGTCAGACTTCAAGCACAGAGCCAT CTCCACGGAATCAAACCTCGCTACACGGGGACTTATAATGCGTACAGAATAATAGCAACA ACCGAAGGCTTGACGGGTCTTTGGAAAGGTAACTAACTTCAAAATGGGTTTTATAACCAC CAAAGCACATACATACAACTAGCAACTTATTGTAAAGTAGAGTTAATAAACATTTTCTTT TTTTTTTTCCCCAGGGACTACTCCCAATCTGATGAGAAGTGTCATCATCAATTGTACAGA GCTAGTAACATATGATCTAATGAAGGAGGCCTTTGTGAAAAACAACATATTAGCAGGTAA CTTCCCATTTCATATAACAAACAGGTCTGCACCTTTAGAAGTTCATCTTGGAGCTTCTGC AGCCACCTTATACTCAATCTCTTAACTCCAATAGTTTTCTCTTTTTAAAAATTAAGTAAT TTTGAACCATATATAACTTTGTGAGAAGCAGGAAAAGACCAAAATATTAAGTTTAAGAAG TTTTGCCACAACAAAAATATTTTGCAACAAAAATAACAGGCAATTTCATGTCAGCATTAT TCTCATTTAATACTAATATATGGGACTTTTGTTAGAATCTTATTCTTTATACAGCAGAAT TCAGGAGGTAAGTCCATCCTGCATACTATATCCAAAAGATCTAGTTATAAAAGGAGCTTA TCAGTGGTCTCATCCAAAAAGTAATACCATAAGATAGGTTCTTAAAAATAATATTCTAAC AACTTCTAGAGACATTGAAATTTCCCTTATTTCAATAAAAAAGTATTAGATGCTCATATA TTAGGCATTATTACAGGCCTTAAAGGCACAGAGGAAACTAACAGTTTACTTTCCTAAAGT GTTAACAATCTATTAAGCCATTTACTCTTTACCTTCTTTTTCTAGTGCAATACCTTTCTT ATTTTATTTTATTTATTTATAAGACATCTTCATTGACCTACTGTTATCAATAGGTTTATA AAGATATGACAGATAACTAAATTGCAAGCCCCCAAAAGTCTGATGTTGACCTGTTTCATC GATCCATTTTAGATGACGTCCCCTGCCACTTGGTGTCGGCTCTTATCGCTGGATTTTGCG CAACAGCTATGTCCTCCCCGGTGGATGTAGTAAAAACCAGATTTATTAATTCTCCACCAG GACAGTACAAAAGTGTGCCCAACTGTGCAATGAAAGTGTTCACTAACGAAGGACCAACGG CTTTCTTCAAGGGGTAAGATATGATCTTGTGTATCTGTAATGTGTTCTGGCTGTCTGTGT GCTTTGGGACACTCTCATGTCAAGCAACCGACATTTAGCTTACAAGCCTTAGTATATTCA TATACTTAGTATTGACTTTTCCTTGCCACAGATTTCTCCAATCCACCAATTCCACTGTGC CAGAAAGTAAAAAGCCATGATATTCAAATTTTCTCAACTTTGATCAAAGGCTCATTCAAG ACCAGTGCCTTTTCCACTGGTCCCAATCTACTGGAAATGCAGACAGTATTTTGCCTTCTC TGGGCAAGAAAGTTATAAAGTAGAGGGAAATCATAATAGAGAGCTATGAGAGAACAAGAT TTGATTTGATTTAATTTGATGGACTCAAGTTTTAACATTGTAAAACTAGAGATAAGACAT CACCACCAATCTAGAAAAGTGATGCAGAAAAGTATTTGATTTGGGTAATTATTACACTCA CCTAGAAACAAGTGTTGTGTAATAGATTACATATTTCCATAATGCAATGTTGTATCAGAA ACTACCTTCCTAAGAAAATATAGTATGGGCTCGGCGTGGTGGCTCGCACCTGTAATCCCA GCACTTTGGGAGATGGAGGCAGGAGGATCACTTGAGCCCAGACTGGGCAACAAAGCGAGA CCCTGTCTCAACAAAAAATTTAAAAATTAGCTGAGTGTGGTGGCACGCACTGATGGTCCC CTCTACTTGGGAAGCTGAGGCAAGAGGATCTCCTGAGCCCAGGAGTTCAAGGTTTCAGCG AGCTATGATTGTGCCACTGCACTCCAGCCTGGGAGACAGAGCAAGTCCCTGTCTCAAAAA AGAAGAAGGAGAAGGAGGAGAAAATACAGTATTAAGTAATCTGTCAATATATTCCACAAG GATTACACTAGTGGTTTAATAATAAAATTATATTACCTTTTTAAATTGTAAGGCCATTCC TCAAGCTTTATAAATTAAGCATGAATGCATCATACACATTTTATAAAAAGTTCCAACTCA TCATAATCTGTACTTATGATACATTAATACAAATGAAGTTCATTATAAAATTAACTTAAA ATGGATATACCAGTTATTAAACCATTAACCATTTAATAATTTTATTTTTTTCAAATTTAA AAACCTTTTGGGGAAGAAATACTACAACATGGATGAACCTTGAAAACGTTATGCTAAGTG AAATAAGCCAGACACAAAAGGACAAATACTGTATGATTACACTTAAATGAGGTACCTAGA GTAGTCAAATTCATAGAGACAGAAAGAATAGAAGTTACCAGGGGCTGGAGGTAGGAAAAA ATGGAGAGCTGTTTAATGGGTAGAGAGTTTCTTTTTGGGGTGACAAAAAGGTTCTAGAGA TGGATAGTGGTGATGGTTACACACAATGTGTGTGTACTTAATGCTACTGAAATGTAATTT TATGATTTTTTTTTTTTGCAGCAAAATACCCCACATTGGGAAGTGAAGAGAAACATGTTA AGAGACTTGAAGGAAAAAAATTGGGGCAGAGGGGTGTTTTTTATAGGTTAAACAATAAAA GCCATTTAAACAGTAACAATTTCTCTAAGGACAAGAATCGTCAAGATTGAGACAGCACTG ATTTCTTGACTCTACTCAATACTTCTTTGGTTTCTCTTCTTCCTTCCCCCTTCTAATAGT TTCCTACCTCCCATTCAGAAAGCAAAGCAAAACAAGCAAAAATTCCCCCTTCCCTCAAAA AAGGAAAGAGTTTTTGAAAAAGTTCATGTCAGTGAAGAAAAGACATGTTTTGGGAGTGAA GGATATTTGTGGATTTGTATAGATGTGATCATCAGGGCTGTGTTGTTTTGAAGTAATATA GGACATCTAGAGGAAAATTTATTTTCAGCAGAGGAGGGAAAGATGAAGAGTAGGTACTTT TAAGCATCTTCACTTGAGGAGTGGCAAAATGAGAAGCATAACCTGCTATAATCACTTTAA GAATTTCAGGCTGAGTGTGGTGGTGCAGTCTCTAGTCCCAGTTACTCCAGGAGGCTCAGG TGGGAGGATCACTTAAGCCCAGGAGCTCGAGGTTGCAGTGAGCTATGATTACACTACTGC ATTCCAGCCTGGGCGGCAGGGTGAAGCCTCATCTCAAAAATTAAAAAAAAAAAAAATCAA ACAAATTAATCGAACGATGACATGCACTTTTCTAGGTTGGTACCTTCCTTCTTGCGACTT GGATCCTGGAACGTCATTATGTTTGTGTGCTTTGAACAACTGAAACGAGAACTGTCAAAG TCAAGGCAGACTATGGACTGTGCCACATAA OMIM ID 113730