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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UCP2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7351 Official gene symbol UCP2 Full name uncoupling protein 2 (mitochondrial, proton carrier) Aliases ,BMIQ4,SLC25A8,UCPH, Gene summary Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq] Location Chromosome: 11   Locus: 11q13 Gene position 73693889 - 73685716  Map Viewer Gene orientation minus Gene size 8174 bp Gene sequence >UCP2:complement(18991511..18999684):Length=8174 CACTGCGAAGCCCAGCTGCGCGCGCCTTGGGATTGACTGTCCACGCTCGCCCGGCTCGTC CGACGCGCCCTCCGCCAGCCGACAGACACAGCCGCACGCACTGCCGTGTTCTCCCTGCGG CTCGGTGAGCCTGGCCCCAGCCCTGCGCCCTTTGCGCCCCCCACGCTTGTTCTGCGTGCG CTGCCCGCTCTTCCATTTACCTTCTCTCCCACCCAAGTTTGTACTCTTTTCTTTCTCTCG GTTTTATTTTTTGTTTTTGTTTGTTTGTTTGAGACAGGCTTTCGCTCTGTCTCCCAGGCT GGAGTGCAGTGGCGCGATCTCGGCTCACTGCAGCCTCCACCTCCCAGGTTCAAGCGATCC GCCTGCCGAGTAGCTGGGATTACAGGCGCCCGCCACCACGCCTGGCTAATTTTTGTGTTT TGTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGCCTCGAACTGCTGAGCTCAAGCAA TCCGCCCGCCTCGGCCTCACAAAGTCCTAGAATTTTAGGCATGAGCCTCCGGGTCCGGCC TGTGCTAATCCTTTCTGTCCTTGGTTCTTTATTTCTCTTCTCTCTTTTTCTTAGTCCCTT TTGTTCTTTCCCTCTCCCGTTCAGTTGGCTGTCGTTTGAGCCTCCACCTTTTCACTCCCT CCTTTCCACCACGATGCCGAGCCCTGCCTTGGATGGGGACCATCAGCGATGACCACAATG ACCTCTCCCTTACCAGGCAGCTCCAGGCAGTGTTCCTGCACCGCCTTTCCCAGGGCTTGG GGGCTTTTTCTAGTGGGCTTTGAGCTGCTCAATCTGGCCTCTGCAGGGCCGGCTCCCAGC CCTTCCAACCTCCTCACAGCCCGACCTGGGACCTAGCCAATTCCCGGAGAGTCTCTGTCC CATCGTGACCCCCTCACAACTCTCCCACTCACCAAAGTCTGATGACTGTGCTAGGGGGTG CTTATATAGAGTACTGAGTGTTACAAAAGCAGAAGTCTGGATGAGAACCAATTTGTGATA TTAAGCAGGTGGGGTGGGGGTGGGGAGTGTACCTAGGTTCATTTTCCGCCCTGCTTTTCC CCTTTCCAGTGTGTGCACTTAACCAGTCCCTGGGCCCTGTTCCCCATCCCCCTCCAAGGC ATGGATTGGGTGGGCTTGTGTGTCTTGGGGCAGGTGGCCCTTTCTAAACTCTCTGCCTTT GCTCACCCACAGGACACATAGTATGACCATTAGGTGTTTCGTCTCCCACCCATTTTCTAT GGAAAACCAAGGGGATCGGGCCATGATAGCCACTGGCAGCTTTGAAGAACGGGACACCTT TAGAGAAGCTTGATCTTGGAGGCCTCACCGTGAGACCTTACAAAGCCGGGTAAGAGTCCA GTCCAAGGAAGAGGTCTCTTGCTGCCTCCTAACCCTGTGGTCTAGGGGCAGGAGTCAGCA GGGCATTAACAAAAATAATTACCATCCCCACCCCCGACAGTGAAGTGGCTCTTTCCAGTT CACAGAGCACTCTCACACCTCCCCGCTCTCATTCTGGCCCTTCAGCTGACTCGGACAAGC CAAGGATCTTGGTCCCCATTTTATAAAGGAGAAAACTGAGGCCCACGTGTAACAGTGATT GGCCCCAAGTCATCCCGGGAGCCAGCAGAAGAGCTAGGACAGGAACCTATTGTTCTAACT TCATATTGATGCTAGCTTTTGACTATCCCTGAAACCGAGATTGGTAATCAGCCCGGCTCT GAAACTGGTTATTTGCTGGGGACTGTAAAATAGGATTAACTATTTCTAGTCCTGCATTTT AATTGCTGTTAGTAGGGCCATCTTACCCACCCTCTGAAGGACCTGACTTGGCAAGCCCAA GGCAACATTCAGAATATGGCAGCTGAACCTCTGTGCACTTGTCTTTGGGCAGCAGCTGGG TCTTATTCTTCTCTGGCCTTCACAACATCCTGCAACCCAGCTCAAGGTCAGGAATGTGAC AGACTCATGTCATCATATCTCTGATGCCCAGAGAAGGGATACCATTTGCCTGAGCCTTCT CAGTACTGTTTAATCAGCCTGTGAGAACTTTCCTTGTGAAAGGCCCTGTCTGTGCCTGGG GCTGATAAAACAGCAAGAACGAACTGAGGAGCTGGGCAGCAGTGCAAAGCAAATACTACC AGCTTTGGTGCCTGTAAGTGTGGCTCTTACTCATCTCACATGGAAATAAGGGCAGCCACC TTGCAGGGCTGCTCTGAGGATTGAGCTAATACAGTGCCCTGGGCGTTGGGGTGGGGAAAG TTGTGGAGCACCTCCTGGGGGAAGGGGGTGTCAGAGCAGGGAATCTGGGGAGTCCGAGGG CACCTTCATCAACCCAATCTGTCATTTGAGCACCAGTCTTCACTGAGCCTCGTGGGCAAG CTGGAGGGAAACAGGAATAAGGTCAGGCCCTGTTCTATAGGTCCCAGTGTAGTTGCTATG GTGAGTATCTTCATTTCCCTGCTTGCCCCAGCCACCTGGAGTGAGAAGCCCAAGAGGAAG CTGGGTGAGCTGTTTGTTTCCATGGGTCTCTGTGTTCACAGCTGACTCCCTTCACCAGCC AGCCCTTTCACCTGAGCCCCAGCAACAAAGGCAGTCAGGCGGGGCTCAAAGCAGCTGCTC CAATGAAGTCAAAGAAATAAGCTCAGGGGAAGAAGCAGGTCACCCTCCCCCACTAGGGTG CTGGGCTCACTTCCTCCTGGGGCAGTGGAGGAGGGTGTGGTTCCAACTCAGAACAAAATG GGGCTTTTGGTTTACTTTATCACTCTTCACAGCTCTGACCTGGACCCCTCATCCCTGCCT GTCTTGTGGTGTAAGTGCGGATCCCCCTAAGTTGGAGGAAAGGAAACTGGCCCAAACAAA AAGGAGAGCAGTTTTCTCTGCATCACATGGTAGGCCAGGAGGAGTCTAATGCCCCAGAGT TTACTCTCAGCCCCCAAAATCACCTAGCTAAATGTTACCTTATCTAAGAAGTCCTTAGGT TTTTTGGGGTTTGTTTTTTTTTTTTTTGAGACAAGGTCTCACTCTCTCACCCAGACTGGA GCACAGTGGCACAATCACAGCTCACTGCAGCCTCAACCTCCTGGGCTCAAGCAATCGTCC CAAGTAGCTGGGACTATAGGCCTGCACCACCATGTCCAGCTAATTTATTTTTATTTATAT TTTTTAGACAGGGTCTCATTATGTTGCCCTGGCTGGTCTTGAACTCCTGGGTTCAAGCAG TCCTCCCACCTCTGCCTCCCAAAGTGCTAGGTTTTTTTTTGTTTGTTTGTCTGTTTTTTG AAACAGAGTCTTGCTCTGTCGCCTAGGCTGGAGTGCAGTGGCACGATCTCAGCTACTGCA ACCTCCACCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCTAAGTAGTTGGGAATA CAGGCGTGTGCCAACACACCCAGCTCATTTTTGTATTTTTAGCGGAGATGGGGTTTTGCC ATGTTGGCCAAGCTGGTCTCAAACTCCTGACCTCAGGTGATTCGCCCGCCTCAGCCTCCC AAAGTGCTGGGTTTACAGGCGTGAGCCACCACACCCAGCCCAAGAAGTCTTTTCTGATCA CCCACTCTTCCTTCTCTCCCAATGGCATTAGTTGTTCCCTCCTTTGCATTTTGAGAGTAT GTCCTGTAAGCCCCAAATGCAGCTTGAATCATCTGCCCATCCACCCCCTGTGCCCAACAG TAAGCCTCCTCTAGAGTAGATACTATCTCCTGCATCTCAGTGAACCACTGCCCAGCAAAG CAGTCTTGCTAAAACAATGACTCTAGAGATCCTAAGCTGTGTGAGAGCTGGAGGAGAGAA TTAGACTGATGGTCTGGGAAGGGATTGAATTAGTCATCTTGTACCTTTTCTTCTTGACTT AAGTTCCAGACCTGTAGCAACCATTCCTGCTTAGACATCCAGAACATAAGCCTATGGGTC TGTGCCTGTTGGGTCTTAGTCTGGGTGAAACTTTTCTCTACTTCTGTCAGCTCTCCAGAT GAACCACAGAAGCAGGAATGTGGGCATCATCAGTGAAATCTCTGCATACAGCAGACAAAG GGCTGGTCCAGTGGCTGTTTATGAGGCAGCGCTAGGAGAGCTCTGATCCAGACTCTCCCT GCAGTGAAAGGGAGGGAGCCCTTCATGAAGTATTGACTGCTTGAGCAGGAATTGCTTCAC CAGCACCTAACTGAGTGCCTCTCGAGCTCACATCGGTTTTCCCTCATGAGGCCACTTGGA GTCTTGCTGAGGGACTTGGTTCTATTAGGGAAGGTGAGTTTGGGGATGGTGAGCAGGGAG GGCCTGGGGACATTGTGGCTAATGGGGCTTTTCTCCTCTTGGCTTAGATTCCGGCAGAGT TCCTCTATCTCGTCTTGTTGCTGATTAAAGGTGCCCCTGTCTCCAGTTTTTCTCCATCTC CTGGGACGTAGCAGGAAATCAGCATCATGGTTGGGTTCAAGGCCACAGATGTGCCCCCTA CTGCCACTGTGAAGTTTCTTGGGGCTGGCACAGCTGCCTGCATCGCAGATCTCATCACCT TTCCTCTGGATACTGCTAAAGTCCGGTTACAGGTGAGGGGATGAAGCCTGGGAGTCTTGA TGGTGTCTACTCTGTTCCCTCCCCAAAGACACAGACCCCTCAAGGGCCAGTGTTTGGAGC ATCGAGATGACTGGAGGTGGGAAGGGCAACATGCTTATCCCTGTAGCTACCCTGTCTTGG CCTTGCAGATCCAAGGAGAAAGTCAGGGGCCAGTGCGCGCTACAGCCAGCGCCCAGTACC GCGGTGTGATGGGCACCATTCTGACCATGGTGCGTACTGAGGGCCCCCGAAGCCTCTACA ATGGGCTGGTTGCCGGCCTGCAGCGCCAAATGAGCTTTGCCTCTGTCCGCATCGGCCTGT ATGATTCTGTCAAACAGTTCTACACCAAGGGCTCTGAGCGTGAGTATGGAGCAAGGGTGT AGGCCCCTTGGCCCTTTTTTCTCAGTGATGATTGATCTTAGTTCATTCAGCCATATAGTT TTTTAGGCCCCACGATCCCTAGGAAGATCAGGGGAACAGAGAACTGGAAGGGGCCCTGGT CCTCCACATAGTTCCTAAGCACCTGGGCTATACCAGGCTCTGAGCAGGGCGTCATCCCAT CACAGTCTTCAACACCACCTTGGGAGTAGGTAGTATCATCCCAGTGTTATAGAAGAAGAG ACTGAGGTGGGAAGGCAGTGGGTAGAGTGGGGACTTGGCCAGGGGCACACAGTAGAGAGC CAGAAAACACACAGTAGAGAGCCAGGACACTCGTCTCTAAGGCCAGCGTTCTTCCCTTTC ACCTCCTTAGTATGCCATGCCAACCCTCCATTTTACACATGACGAAACAGAGCCCCAGAC AAAAGGTTGTCTTTCCCAGATCACATGGCAGGAAGAAGTAAAGCTGACCTGAGATCCCAA GTCTTAGGAATCCCAGTCCTCAGAAAGCCACTTCTCTCTGAGCCTTGGTTTTCACATTTG TCAGATGGAAATGATTGTGATTTCTCAGGGCTGTTGAGCAGGTAAATGAAAATGTTTTAT GAAAGAAAGCACCAAGTTTCATTTTGGTCTTAGCCCTTGCTATGTCCCTAGCAAGAAGTA GATATTCATAGGGATATTTTGTTTGATGTGAGGAGTTCTTACAGCAAGAGCTTGTAGAAG GCCAAAAGCTTCTGGATTCTATTCCCAAAAGCAGGAGATGACAGTGACAGGGTGGTTTTG GTGAGGAGAGATGAGGTAGAAAATGAGTGCAAGCCCGCTGGCCACTGACCCCATGGCTCG CCCACAGATGCCAGCATTGGGAGCCGCCTCCTAGCAGGCAGCACCACAGGTGCCCTGGCT GTGGCTGTGGCCCAGCCCACGGATGTGGTAAAGGTCCGATTCCAAGCTCAGGCCCGGGCT GGAGGTGGTCGGAGATACCAAAGCACCGTCAATGCCTACAAGACCATTGCCCGAGAGGAA GGGTTCCGGGGCCTCTGGAAAGGTGTGTACCAGTTGTTTTCCCTTCCCCTTTTCCTCCTC CCCGATACTCTGGTCTCACCCAGGATCTTCCTCCTCCTACAGGGACCTCTCCCAATGTTG CTCGTAATGCCATTGTCAACTGTGCTGAGCTGGTGACCTATGACCTCATCAAGGATGCCC TCCTGAAAGCCAACCTCATGACAGGTGAGTCATGAGGTAGACGGTGCTGGGTCTCACCCT TCCCCCATGCCAGGAGCAGGTGCGGGGGTCTAGCTGACACCAGAAGACCACATCTTTTCA TCCTATTTGCCCTTTGCAGGGAGAGTAAGATATCTCTTACTTGCCATATTGAAGCCAATT GGGATGAAGCTCCCACTTTGCACATTGAGGAACTGAGGCTAGATTGGCAAAATGACTCTT TCAGGTCCTCAGAAGATGTCTCAGCTGGAGTCCCTGTCTGTTTTTGTTTTTTTGTTTGTT TGTTTTTTGTTTTTTTTGAGATAGAGTCTCACTCTGTTACCCGTGTAATCTCAGCTCACT GCAACCTTCTCCTCCTGGGTTCAAGCGATTCTTGTGCCTCAGCCTCCCGAGTAGCTGGGA TGACAGGTGTGCACCAGCACACTGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTCA CCATGTTAGCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCTGCCCACCTTGGCCTC CCAATGTGCTGGGATTACAGGTGTGAGCCTCTGCGCCCCATCCTCTTGTTTGTTTTTTGA GACAGGGTCTTGCTCGGTTGCCCAGGCTGGAGTGCAGTGGGGTGATTAATGGCTCATTGC AGCCTCGACCTCCCTGACTCAAGCAATCCTCCCACCTCAGCCTCCTGAGTAGCTGGGGCT GACTACAGGCATGCACACTGTGCCTGGCTAATTTTTGTATTTTGTAGAGACAGGGTTTTT GCCATGTTACCCAGTCTGGTCTTGAACTCCTGGGCTCAAGTGATCCACCCACCTCGGCCT CCAAAAGAAGTCCTGGATTACAGGCATGAGACATTGTGCCCAGCCTCTCTGTCTCTTTAA AATCATGAAAACTCGTAGCTACTTAAGTAATTCTCCTGCCTTCTGGAATGATGGGTGAAG ATCTTGACTGCCTTGCCTGCTCCTCCTTGGCAGATGACCTCCCTTGCCACTTCACTTCTG CCTTTGGGGCAGGCTTCTGCACCACTGTCATCGCCTCCCCTGTAGACGTGGTCAAGACGA GATACATGAACTCTGCCCTGGGCCAGTACAGTAGCGCTGGCCACTGTGCCCTTACCATGC TCCAGAAGGAGGGGCCCCGAGCCTTCTACAAAGGGTGAGCCTCTGGTCCTCCCCACCCAG TTCAGGCCTCTTGGCTATGCATGTCTATTGTGGGTGGGAGAGAACCACCTGGAAGTGAGT AGCAGCCAAGTGTGACTATTTCTGATCCTGGTCCTGGCATTTCACCAGCATTCACCTATC CCCTTAATTCCTTCCTCCCAGAATTGCTACCATCACTGTTTATTAGGTGTTAAATGGAGA CTCAAAGGGAATTCATGCTTATAGCCAAGCAGCTGTGAGCTCAGTTCATTGAGTCCTCCC AGCCTCCTTTGGGACAGAGCAACTGGGTTGGATTGAATACCAGGCCCAGTGAGGGAAGTG GGAGGTGGAGGTGCCCCCATGACCTGTGATTTTTCTCCTCTAGGTTCATGCCCTCCTTTC TCCGCTTGGGTTCCTGGAACGTGGTGATGTTCGTCACCTATGAGCAGCTGAAACGAGCCC TCATGGCTGCCTGCACTTCCCGAGAGGCTCCCTTCTGAGCCTCTCCTGCTGCTGACCTGA TCACCTCTGGCTTTGTCTCTAGCCGGGCCATGCTTTCCTTTTCTTCCTTCTTTCTCTTCC CTCCTTCCCTTCTCTCCTTCCCTCTTTCCCCACCTCTTCCTTCCGCTCCTTTACCTACCA CCTTCCCTCTTTCTACATTCTCATCTACTCATTGTCTCAGTGCTGGTGGAGTTGACATTT GACAGTGTGGGAGGCCTCGTACCAGCCAGGATCCCAAGCGTCCCGTCCCTTGGAAAGTTC AGCCAGAATCTTCGTCCTGCCCCCGACAGCCCAGCCTAGCCCACTTGTCATCCATAAAGC AAGCTCAACCTTGG OMIM ID 601693