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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UCP3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7352 Official gene symbol UCP3 Full name uncoupling protein 3 (mitochondrial, proton carrier) Aliases ,SLC25A9, Gene summary Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene. Location Chromosome: 11   Locus: 11q13 Gene position 73720282 - 73711326  Map Viewer Gene orientation minus Gene size 8957 bp Gene sequence >UCP3:complement(19017121..19026077):Length=8957 GAACCAGATCTGGAACTCACTCACCTCCCCTCTCACCTCACTGCCCTCACCAGCCAGCCT CTTGTCAAGTGATCAGGCTGTCAACCAACTTCTCTAGGATAAGGTTTCAGGTCAGCCCGT GTGTATAAGACCAGTGCCAAGCCAGAAGCAGCAGAGACAACAGTGAATGACAAGGAGGGG CCATCCAATCCCTGCTGCCACCTCCTGGGATGGAGCCCTAGGGAGCCCCTGTGCTGCCCC TGCCGTGGCAGGACTCACAGGTAAGACCCCTTTCTCCTCCCTCATCCCTTCCCCTCTCCC TCTCCCTTCTCCTTGTTCTCCCTTTCATTGGAGGCTTTCAGAGAGCAGCCCCGAGCAGTC AGGGCTCACTAGCTGCAGCTTGTCAGACCTGATAGAGATTCAGTCCAGCCGCCACCTTAT GAAAAGGGAGCTGTGGCCTTGATGAGGGTACTGTGGCAGGGCTGGGGCTTGAACCCAACA CCCGTGTCACTCACTCAAGACTCACACCCCCTTTGCCTTGCTGGCTGCCTCTGGTGGGAT TTTGCAAATCCCCATAGACAGGAAGTGGCTTTCTTCTTTGCCTGCCCCAGAATCTCTGCG ATTCCTCCAGAGCATAAATCCCTCTCTTTCCATGAGGACCCTGGGGCCCTCTTCCTGAGT AGGGATGACAGGGGCACTTCTGACCTGAGGCGTGGTCCAGGTCATTTGCTGGGAGCTTTA CAGAGCCCATGGTCTCTGCCCAGACGGCTTCTTCAGTGGGCTGCTGTGAAGGCTTTGCCG GGAGGGTGGGTTGGAGTTGGGGAGGCAACTGGTGTTGGGTAGGATGTCTCAAAATGGGGT CCTCTTCCCCTGCTTCAGAGCTACCACAGGGAGTTTTCCTAATGCAGATTCCTAGGCCCC ACCCCAGACCTAAATCAGGATCTCTGGGGCTGAGAGCTGAGAATCTGCTCTGTAAACAAG CAGCTCAAGGGATCCTTGGCTCTCCCTGAAGTCTGAGACTCTCTGGGCAGTGAAACAGGC GCAGCTTCAGATGTCAGACAAACGTGGGCACCAATCTCAGCTCCAGCACTTCAGCTGTAT GACTAGCAAAAGCCCTGGAAGCCTCAGGTCCCTGGTTTACGAAATGAGAATAATAATAGC AACTACTTGTAGCCTTATGAAGGGATCAAATCAGTCAGTGTCTGTAAAGCCCTCAGCACG GTATCTGGTGCAAGAAGCAACCAGCAAACATTAATGGACCATGCTGACTAGAACATCCCA TCCCTCAGGAGCCCCAGCAGAGCTACAGTAATGAGGGTTCCACTTTTGACTTCTTCCTCC ACTGGCCAGTGGCAAAAGGCTGCCGGCTGCTAGGGGTCTAGGAGAGTCTGGAGTGAATTG GGAAGAAGATTGGGGAGTGCTGGCCTCAAGGCACCTCCTACCTGTGCCCACCACTGTGGC TTTCCCTCCTCCCGCAGCTTGACTACTGAAAGTTCTAGAGCCCCAAGGTGGGCTTTTGAC CTGAGTCTGTGTCCATCCATTCCATTTTCCATGAGTGGCTAAGAACTGCCCCTCTTGTCA AGTGATCACGCTGAGGCCAAGAGTTCAAGACCAGAATAGGCAACATAGAGAGACCCCCAT CTCTACAAAAAATAAAAAATTAGCTGGGTATGGTGATGCACACCTGTAGTCCCAGCTACT CGGGAGGCTGAAGGTGGGAGGGTCACTTGAGTCCAAGAGGTCAAGGCTGCAGTGAGCCTG GATTGCACCACTGCACTCCAGCCCAGGTAACAGAGTGAGACCCTGTCTCAAAAAAAAAAA GGAGGCAGTTTGATATTGGGGAGAACAGATGCCTGAGCCTCGGTTTCCTCATGTATACAG TGCAGGTACCACTATCAGCTCTGCCTACCCCTGGTAAGGAGGGGAGGGAGAGGGTCAGGA GGAGGATTGCAAAATTCAAGGGATAGGAACGTGACCTGTTTTTATAGGCCAAATTCATGC AGCTTAAGTATGGCACCACCCAGGCTTCTCCCTTTCTAAAGCCCCTCCTGGGTAAGGAAG AGTTCCTGGGAGCCAGGCCAGACATCACTCCATCAGCCTTCTCTGGCCTGTCTCCTGCAG CCCCACCGCTGCACTGAAGCCCAGGGCTGTGGAGCAGCCTCTCTCCTTGGACCTCCTCTC GGCCCTAAAGGGACTGGGCAGAGCCTTCCAGGACTATGGTTGGACTGAAGCCTTCAGACG TGCCTCCCACCATGGCTGTGAAGTTCCTGGGGGCAGGCACAGCAGCCTGTTTTGCTGACC TCGTTACCTTTCCACTGGACACAGCCAAGGTCCGCCTGCAGGTAGGTGCCCTTTGGCCAA GGGTCATTGATCACATGGAAGGAGGGGCTAGTTCTCTCCCATATCCCCCATGACGTGTGC CCACATGCCCTTCCTCAGAACCCTGACAAAGACTCTCACTCCACTGCTTAGGACCCTTCC TTGCCTCCTCCCATCACCATCCACCAGGACAAAAAAATCTAAATTCTTTGCATGATGTGA CAGGGCCCTTTATGGGCTAGGCCCTACTTTGTAAAGCATGCAGTGTGAGGTAAAAGTAAG GAATTAACTGTGTGACCTTGGGCAAGCCACGAAGCACTTATAAAATGGGAAAAACAATCT GTCCCTCTGATTTACTCTGAGGATCAAACACCAAGCCATGTGTATAATACTGCTTTGTGA ATGGTAAAATGCTGCGCAGACACCAGTGATTTCTACTGTGACCAGCATGGTTGTTCTCAG GCCCAGCCCAGGCAGGCCCAGCCCCAGCAGGGTTCCTGTGCACGCAGCCCCTTCTTGCCT TCCCATCTGAGTCCTCACCCCCTGCTATTGTCCCTCAGATCCAGGGGGAGAACCAGGCGG TCCAGACGGCCCGGCTCGTGCAGTACCGTGGCGTGCTGGGCACCATCCTGACCATGGTGC GGACTGAGGGTCCCTGCAGCCCCTACAATGGGCTGGTGGCCGGCCTGCAGCGCCAGATGA GCTTCGCCTCCATCCGCATCGGCCTCTATGACTCCGTCAAGCAGGTGTACACCCCCAAAG GCGCGGACAGTGAGTGACCAGGTCCCTGAACACCAAAGGGGTGGCTGAAAGTGTGTGGGT CAAGAGACCAGGGAAGTCTAGACTCAGAGGCAGAGCCAGGGGCGGGGGGAAGCTGGTACC GGACGCTTATGAGGAGGCTCTGAGTGGACATCAAGGAAGCTGCAGGGGCAGCCCCGCAGA GAACAGCATGTCCCAGAATGCTGCTTAGTAGGGGACACTGGCCCACTCTCTCTGCCCCTC CCAGACTCCAGCCTCACTACCCGGATTTTGGCCGGCTGCACCACAGGAGCCATGGCGGTG ACCTGTGCCCAGCCCACAGATGTGGTGAAGGTCCGATTTCAGGCCAGCATACACCTCGGG CCATCCAGGAGCGACAGAAAATACAGCGGGACTATGGACGCCTACAGAACCATCGCCAGG GAGGAAGGAGTCAGGGGCCTGTGGAAAGGTAGGTCTGGACTCTGGACGCAGGCGGTCTTA GGCAGAGCTTTCCCTCCCCTCAGGCTGGGGCAGGGACCCCAGTAAGGAGGGGACTCCCAG CATGGCGTGTTCCAGTGATTCTGAAAGAACATCACAACCAAAGATACTTCACTGACCTGC CACAGCCCCTCAAACTCAGTTCATTTTACCAGCCCTTTGCCATGTGCAGGTTGATGTGAG GGAGCCAGAAATGAACTTAAGACACCTTCACACGCCCAGGGCATGAGGACAGCAGAGGAG ATAAGATGCAGCTACACCACAGGCAGGATGTGGTAGGGGTTGCCCCAGAGGTGGAGCTCC AGAGGCGGGCTCTGCAGAGAAGGTGACACCTAAGCTGGGCCTGGAAGACTGAACAGGCTC TAGGTGTGTGGAGACGGAAGGGGAGGGGCCCTCAAGCAGGGTCCGGAGGAAAAAGAGGAG CATCAGAAAAGCACAGCTGTGAGGAGTGGGCGCAGGGAGATGCAACGAGGAAGCGCTTCC TTGGGAGCAAAGCTGGAGGGCTCCCTATGTGTCCACATGGCAGCCACTGCGATGAATGCA GGACTCTCTCCGCATGTGAACCAGAGGTTGCAGGAACGTTTGCAGAAGAAACTGACCCAG TGAAGTTTAAGGGCAGGACACCTCTTAAGTTGGGGCTCTTCACTCACTTGTTGGGCACCC TTCAGAGCTTGTCCCCTTACCTGTGAAACCAGGGGTTTGATCCTGACAGTTTCCTAGGGC CCTGCTGGCACCACATTCTGTCACTGTTCCAAGAGCTCAGCCTCTCGCTGAATGACTTTC TTTTCTGGCTGCAGCTGGGTCTCCAGGAAGCATATTTTAATTTTGACAGCTATTGCAGAT CACCCTCCAAATGTGGCCAAATGAACACAAGTGGGCCTCTCTGTTCTCTGTCTCTGAGGA AAACATGGATAATCTGAGAGTTGTTAACCCTAGAAAGGAAAATGTGGAATCTGCTCAGCT GGGGTGGGATCCTCTGGCTGAGACCATTGGAATGGGGCACTATGGCCCCAAAACTGGGGC CTGTGGCCTTGCAGCCAGGGCATCCATTTCTCCCATTTCCCATTCCTCCCTCCCCACCCA TTTCACATCCCTCCCCACCGCCTTCCTAACAGGAACTTTGCCCAACATCATGAGGAATGC TATCGTCAACTGTGCTGAGGTGGTGACCTACGACATCCTCAAGGAGAAGCTGCTGGACTA CCACCTGCTCACTGGTGAGGCCCTGGGCTCCAGGCAGGCAGCTCTCCCTCAGCAGGGAGG GAACCCAGAACTCCGTGGAGTGGGCACCACCCAGAGGCAACTGGGTTTTAGAAGGAGCAG AGAGAGAAGCAGTGCCTAGTAAAAAGTGCCAGGTACATTGTGGTGACAAGCAGGAAAGAC CCCTGGGCTGGGAGGCTGGAGACTTGGGTTCCAGTCCCAGCACCACCTCTCACTATATAG CTTTAAGCAGGGGTCTCTCACCTTCTCCGACTTCAGTTTCCTCAAACAGCCTGCATGACC TCCCACCTCTGGGTCAGCCCAGGCCTAGTTTGCCAGTACTTACCAAGAGCTTAGCCCAGG GCACTGTGAGAGATATGGAAAATACTGTCCTATGCTCAGGGAGTTCACGGTTGAGTTGGG GACAAACAGTGCATACATATGGACAGAACACAAATGCACTCCTTGATATTTGCTTGTCCT TCCTCTGCAGACAACTTCCCCTGCCACTTTGTCTCTGCCTTTGGAGCCGGCTTCTGTGCC ACAGTGGTGGCCTCCCCGGTGGACGTGGTGAAGACCCGGTATATGAACTCACCTCCAGGC CAGTACTTCAGCCCCCTCGACTGTATGATAAAGATGGTGGCCCAGGAGGGCCCCACAGCC TTCTACAAGGGGTGAGCCTCCTCCTGCCTCCAGCACTCCCTCCCAGAGAACAGGGGCTTC TTTCTTTTCGAATGTGGCTACCGTGGGTCAACCTGGGATGTAGCGGTGAAGAGTACAGAT GTAAATGCCACAAAGAAGAAGTTTAAAAAACCATGCAAGTAAAAGAAAAAAAGTGAACCA TACCTGATGGGGAGGGTTAGGGAAGCCTGACTGAGAACAAACACTCCAGGAATAGGTAAA AGTACTGCCTGTCTCCAGAGGAAGTTAGCAATCCTGAGACCTCCTGGACCTCCTGCCATG GCCATTGAGCACCACACTGACCATGGCCAGTGCCTTCCTCACTGTCTCCACACGCTCCAC GTTTTCTTGCACTTACTGCTCCCTCTGCGTGGAATGCCTCATCATCTACAGGCTGTCAAT TTTAGCCATCCTTCAAGACGAGTTCAAATGCCACCTCCTCCCTAACACTCTCAGGTGTAA ATTTTTCCTCCTCCCTGGGAACTTCTGCAATGCCATTTGATACCATTTTTATGGTATTTA TCACCTCCTGCCTTGTATTATAGTATTTGTAAGCTTAAATTATTCCTCATGCAAAGAGCA AGTTCCTGACAGCAAAAGTGGCTCAGACATCTTTTATCTCCCACAGTCCCTCACACAAAG TGAGCACTCGATAATGCAGGTTGTTTATGATTATCACAATAGCTAAGTCACTCTATATTA GGCCTCGTGCTGAGCACTTTACACACGTTATCCCAACAGCCCCTTGAACTGGGTAGTATT GTCCACATTAACTAAGGAAAAGACTGAGTGTCAGAAAAGTTAAGTAACTTATCCAAGATC ACAGGTTAAAATGGTGGAGCCATGGCTCAAACCCTGACCGTCAGACACCACACCCAACAA TGTTGTTTATCCTACTGGTAAGCTCTTAGCTTGGCCCTTTCACCTCCCACTGCTGATGTC TTCAACAGAGAGTTTTTTGGTGCCCAGTGTTAGAATGGACCCAACAAGTGAACAAGAGCT GCTATAGGTTCTCAAGCCTGGGAATGACGTAATAAAACTATACTGCAATTGACAGACTGT TCTTCCAAAAAGTGCCTCTATCATTACAGTCTTCAGCTGTAGCCACTTGTCTCAGTTACT GCTTTCACTTGTCCAACATTTCTGGAGCATCTTGTAGGTGCCAGGCCCTGGGTTATGCCT CCCTCAAAGAGCAGCAGATAAGTTGGTGGTATTTACTGAGCATGTATTGATGCTGGGCCC TGTGCTGAGTGCTGTCCAACATTAACTCACCTAATCTGCACGACTAACTCCACAAGGCAG ATACTGTTATTTTCCTCATTTTACAGATAAGGAAACTGAGGCTTAGAAAGATTAAGTGAT GTGTCCAGATTGTAAAGCTAGAAACTGGGAGAGCTTGGATTTGAACCCAGGTCTGACTCC AGAGTTTACATTTGTTGTCACAGTACTATCGTCCCCACAAGAGTCAAGAAAACCCATGGC ATGAGGTCACAGTGCCCAAACTGAGTCCTCCAGAGCAAAGAGCAACCAGCCAGGGAAGGA GGAGAGGAGGGGACAGTCCAGGCAGAGGGAGCAAGAGGAGCAAAGGCATGGAGGGAAGAG GGCCTGGCATCGTCAGGGAATGTGACTAGCTGAGTCTGGTGGGAGCAAACGGGCCCAGGA GGTGGTTAGTGGAGGGACAGGCTGAGAGAGGGGCAGGGGCCAGCTCGTGGGCTTCTCCCT GAGTTGGTGAGCCACAGCTGAGGTGGGGACACTGTGCTATGCCATCACAGCACAGCCAGC CTCTCTGGAGAAGAGCTAAATCTGGTGCCACACTGTATTCACCCTGCAAAGCCCAAGCTT CTCCATGTCCTGGCAGGGGGCCATGTTAGGGCTGGCCACCCGGGGTGTAACTGAGCCCAG AAACACCCAGCAGCAGGGTGGAGTTAGAACCGCACCTCTGACACTTACTAGCCGCGGGTC TTTGGTTGAGCTCTTAACCTCCCTGGGCCTCAGTTTGTGAAAAAGAGCCTGGCAGCAACA TGGCTGCCTTATAGAACTGTGAGAATTCGCTGCCTAACACAGTAACCCGTCTCAAAACGT GAGTTTTTTTTTCTTTTCCTTACTCCGACTTCTGCCTAAATCCCCTTAGCAGAAAAAAAA AAGAGAGAGAGAGACTGAAAGGATTCAGAAAATGCTTGTGATGAACAGAAGTCTGGATCC TCTGGCACTACCACTGTGTCCCGGGAGAGCACACGCATCTGTTGTGGTCCCCTAGCACTC CACCTGATGTGTTGGTTGTTTTTCTTATCAGATTTACACCCTCCTTTTTGCGTTTGGGAT CCTGGAACGTGGTGATGTTCGTAACCTATGAGCAGCTGAAACGGGCCCTGATGAAAGTCC AGATGTTACGGGAATCACCGTTTTGAACAAGACAAGAAGGCCACTGGTAGCTAACGTGTC CGAAACCAGTTAAGAATGGAAGAAAACGGTGCATCCACGCACACATGGACACAGACCCAC ACATGTTTACAGAACTGTTGTTTACTTGTTGCTGATTCAAGAAACAGAAGTAGAAGAGGA GGAGGGATTCTGGTCTTCACTGCCATGCCTCAAGAACACCTTTGTTTTGCACTGACAAGA TGGAAAATAAATTATATTAATTTTTGAAACCCATTAGGCATGCCTAATATTTAGGCAAGA GAAAATAAACCAAGATAGATCCATTTGGACAAAATGGAAGGTTGGAGACGTGTATCCCCG TGAAATCTGGTTAGATAATGAATGATAAGCAGGAAGGATGGCAAGCACGGGACAGGAGGG GCCCACAATGGAGTGGGAGATCAGCCACGGAGCCTGGAGGGATGCCACCCAGCAACACAG AGCTGGCGACTGCAGCTGCACCATCACACATGCATCATCAGCCTATTTGTAATATGTCTG CCACAGAGAGTCCTTTGGGATTCTAGGAAACCCAAGGAACAAGAGAAAAAACTAGAGCCT GTGCTAAAGAAGCCCTGCTGGGCCCATGTGAGGCTGGGGCTCGTAAATATTCCCTGACGA CACTGAAGAATCAAGAGGGCAGCCCCCACTTTCCTACAAAATGGAGGGAGCCATCCCTTC CCTGTCCACCTCACCAGGGGTGCTATGACATGCAAGTGAGAAGCTGGGCATGAACGCACT TTATAAAAGCAAAAGCTCTGTGTAAATCTAACTACAAGGACAATGCCTTGGGAGAGATTT TGTCGGGACAGAGAGGAGTTGCCAGGGAAGAAGGTTTGAAAGATACGGTTGTCTAGAGGT GAGACCAAAGGATCCAGAGACTTGGGGACCAGAGGTGACAGTGGATGACGTGAAGCCACA GGAGCCCCACCCCCATGCAGCCTCTTCCCCACCCCCCCCACCACGTGCTCAATCATGAGT ACCTCAAAGGATTGTTGGGCTTGGGGGAAAAGAGGTGGATTCCTGGGCAAGAACCTAAAG TAGCAGGACTCGGAATTCTCGGGAAATTATTATGACTCAATAAAAGAATTCACACCTTAG GTGTGGGAGTAAGAACA OMIM ID 602044