Entrez gene ID | | 7374 |
Official gene symbol | | UNG |
Full name | | uracil-DNA glycosylase |
Aliases | | ,DGU,DKFZp781L1143,HIGM4,UDG,UNG1,UNG15,UNG2, |
Gene summary | | This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q23-q24.1 |
Gene position | | 109535415 - 109548798 Map Viewer |
Gene orientation | | plus |
Gene size | | 13384 bp |
Gene sequence |
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OMIM ID | | 191525 |
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