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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for WFS1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7466
Official gene symbolWFS1
Full nameWolfram syndrome 1 (wolframin)
Aliases,FLJ51211,WFRS,WFS,WOLFRAMIN,
Gene summaryThis gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
LocationChromosome: 4   Locus: 4p16
Gene position6271577 - 6304992  Map Viewer
Gene orientationplus
Gene size33416 bp
Gene sequence
OMIM ID606201