| Entrez gene ID | | 7520 |
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| Official gene symbol | | XRCC5 |
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| Full name | | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) |
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| Aliases | | ,FLJ39089,KARP-1,KARP1,KU80,KUB2,Ku86,NFIV, |
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| Gene summary | | The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq] |
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| Location | | Chromosome: 2 Locus: 2q35 |
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| Gene position | | 216974020 - 217071016 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 96997 bp |
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| Gene sequence |
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| OMIM ID | | 194364 |
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