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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for YWHAE (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7531
Official gene symbolYWHAE
Full nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Aliases,14-3-3E,FLJ45465,FLJ53559,KCIP-1,MDCR,MDS,
Gene summaryThis gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq]
LocationChromosome: 17   Locus: 17p13.3
Gene position1303556 - 1247834  Map Viewer
Gene orientationminus
Gene size55723 bp
Gene sequence
OMIM ID605066