| Entrez gene ID | | 76688 |
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| Official gene symbol | | Arfrp1 |
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| Full name | | ADP-ribosylation factor related protein 1 |
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| Aliases | | 1500006I01Rik,AI480700,MGC6837 |
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| Gene summary | | The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
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| Location | | Chromosome: 2 Locus: 2 H4 |
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| Gene position | | 181100109 - 181092395 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 7715 bp |
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| Gene sequence |
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