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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PCGF2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7703
Official gene symbolPCGF2
Full namepolycomb group ring finger 2
Aliases,MEL-18,MGC10545,RNF110,ZNF144,
Gene summaryThe protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q12
Gene position36904558 - 36890150  Map Viewer
Gene orientationminus
Gene size14409 bp
Gene sequence
OMIM ID600346