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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ZP2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7783
Official gene symbolZP2
Full namezona pellucida glycoprotein 2 (sperm receptor)
Aliases,ZPA,Zp-2,
Gene summaryThe zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p12
Gene position21222868 - 21208773  Map Viewer
Gene orientationminus
Gene size14096 bp
Gene sequence
OMIM ID182888