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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DAP3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7818
Official gene symbolDAP3
Full namedeath associated protein 3
Aliases,DAP-3,DKFZp686G12159,MGC126058,MGC126059,MRP-S29,MRPS29,bMRP-10,
Gene summaryMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5' UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q21-q22
Gene position155658874 - 155708320  Map Viewer
Gene orientationplus
Gene size49447 bp
Gene sequence
OMIM ID602074