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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAPKAPK3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7867
Official gene symbolMAPKAPK3
Full namemitogen-activated protein kinase-activated protein kinase 3
Aliases,3PK,MAPKAP3,
Gene summaryThis gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p21.3
Gene position50654601 - 50686719  Map Viewer
Gene orientationplus
Gene size32119 bp
Gene sequence
OMIM ID602130