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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MANF (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 7873 Official gene symbol MANF Full name mesencephalic astrocyte-derived neurotrophic factor Aliases ,ARMET,ARP,MGC142148,MGC142150, Gene summary The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq] Location Chromosome: 3   Locus: 3p21.1 Gene position 51422692 - 51426828  Map Viewer Gene orientation plus Gene size 4137 bp Gene sequence >MANF:6584..10720:Length=4137 GGAGGCGGTGCGGCGCGGCGGGTGCGGTTCAGTCGGTCGGCGGCGGCAGCGGAGGAGGAG GAGGAGGAGGAGGAGGAGGAGGATGAGGAGGATGTGGGCCACGCAGGGGCTGGCGGTGGC GCTGGCTCTGAGCGTGCTGCCGGGCAGCCGGGCGCTGCGGCCGGGCGACTGCGAAGGTGC GGGATAGGGGGCCGGGGGCCGCGCTCCGTGACCGTTCTGGCGGCGGCGCTGAACCCCACA ACATCACCAGACGGCCGGGGCCAAGAGGGCGAGGGCGGGGGCGGGGGCGGGGGCGACAGC AGGTCCCCGCGGGGCCTGCATGAGGAGGCTCCGGCGCCCGCCCTAGTAAATCTTTCTTGG GCCTAGAAAACATTGGTCCGACGAAGAAAAGTTGAGACTAGATCCCGTTGAAAACTTGTC CTGAAATCTCCATCACTCCTGAGTTATTGTCCCCACCACCATCTAGAGGTTACCGCTCCC CGTTCGGCGTCGGGAGCTCCAGGGCTGGCCGTGGGTGCTGCGCCCTGTCTGTTGGGATCA CGAAGCTGCACCTCTGGGTCCGCTGTTGTATTTGGAAATTAGCAGCAGCATTTTGATCAT TTTTCTCTTCACCTTCCAGTCTCTCCATTTATGAGGTCACAGTGAGTCCCGTCTCAAGGA CACGTGTTCACCATGGGCTTAAACTTGATGAAAGGAGCAGGGAGAAGTCGTTTATAGGTC ATTGGGTGATGCTTGGTCCTTTGATGCCCTGGGTGTACCAGGGGACCCCCGCCACTTGGA ACCGGGTTCTGTCTACCTGTAGACACCTGAGAAAAATCGGTGATGGAAAAGCTCACCTCT AATGATTCATCTCCGTGTCTCCTATTAAAATTGCTGGCGGAGTTCTTTTCTGGTGGATTG GAACAGCTTGGTGATTGCTGAGCATCTCCCGTCCCTCTCTTTTCCAGTTTGTATTTCTTA TCTGGGAAGATTTTACCAGGACCTCAAAGACAGAGATGTCACATTCTCACCAGCCACTAT TGAAAACGAACTTATAAAGTTCTGCCGGGAAGCAAGAGGCAAAGAGAATCGGTTGGTAAG TAGCTGGTGATCCTCCCCAACTGGCCCTGGCTCATGTTAACCCTCGGCTTCACCAGCCGT TTGATAAAAGGCCTTGCCCACCTCTCTGTTCAGGAAGCCAGCTACTCTCTCCATAAACTA ATGTGAGAAGACTGAAGTGCTTCTATGTCCTTCCCAAAGCAGCATGTGTTCTGCAACTGT GATTTTTTTTTATCCTGTTAGTCTTTATTAAGCACCTACTATGTGCTAGGCACTGGGAAT ATCAGGGGAAAGAAGTGACAGTCGGACACACAAATAATGCAATGTCTGGGTGTCATGAAG AAAATGGACCAGCAGGTGCTGATTTAGAGTGGCCAAGAAGTCTCTGAGGAAGGGTTATCA TTGAAGTGGGGTAAGACCATCCCATACAGGGAACAGCAGTGTGAGTGCCCAGAGGCCTGA AAGAGTGTGGCATGTATGTGGACAGGAGAAGGTGACAGGGTGCCTACAGGATAGGCAAGG GCCGAATCCAAGACAAAAGCCCTAGTGAAGCAATGGGTTTTCTAACTTGAATTTCTCTGA CAGTCTCTGGCTTTTCTCTCTGTTAAAGGTTTGAACCCTGGTGACACTTAAATTCATTTG GTGGCTGTCAGCTTGGACTGAGCATGTGTTAAGAGTCCAGGGTTTACACTGGCTGAATCT GACTACCAGTACAGGCAGGGCACCGAAAAATGCCGCTGTGGGCCAGGTGCGGTGGCTCAT GCCTGTCTTCCTAGCACTTTGGGAGGCCAAGGTGGGAGGATTGCTTGAACTTAGGAGTTT GAGATCAGCCTGGGCAAAGTGGTGAAATCCTGTCTGCACAAAAAAATTTTTAGGCTAGGC GTGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGACCGAGGTGGGTGGATCACCTGA GGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACTCTATCTCTACTAAAAAATA CAAAAATTAGCCAGGCATGGTGACAGGCGCCTGTAATCCCAGCTGCTCAGGAGGCTGAGG CAGGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGCCAAGATTGCGC CACTGCACTCCAGCCTGGGTGACAGAGCAAAACTTTATCTCAAAAAAAAAAAAAAATTGT TTTAGTTAGCTGGGTGTGGTGGCCCACACCGGTAGACCCAGCTACTAGGGTGGCTGAGAG GGGAGGATCACCACCCAACAGATTGAAGCTGCAGGGAGCCGTGATCATGCCACTGCATTC CAGCCTGGGTGACAGGGAGCCCTATCTCAAAACACAAGTAAGGCCCTACAGAGAGATGAT GTTTCAAGGTGTCAGTATGTTTGGAGGAGATGGCTCTCAAGCACCTCCTGAAGGCCATTG TCCTTTATTGCTCCAGTGCTACTATATCGGGGCCACAGATGATGCAGCCACCAAAATCAT CAATGAGGTATCAAAGCCTCTGGCCCACCACATCCCTGTGGAGAAGATCTGTGAGAAGCT TAAGAAGAAGGACAGCCAGATATGTGAGCTTAAGTATGGTGAGTATGCCTAGTCCTTTCT TAATGAATGCTGTGCACCTTCTGGGTTTGTTTCCCATCTGGGAGAGGAAAATGATGAGCT AGAGTCATGAGTGGGTTGTATTGTATGACAGATGGTGCTAAATGCTGGAGGGCTCTGGCA TGGAAGTGGGTGGAGGTCAGAATAGGCCTTATTGAAGAAGTGATATTTCAGCAAACTTTG AAGGAGGTGAGGATTAGCCAAGAGGCCAGCTAATGGAAGAGGATACAGGCAGGATAAAGG TGTCCAGTGGCATGGCAAGTCAGAGAGCATTGCAGGCTGGTGAGGGCTTTTAATCTGCGT GAAGTTAGGAGCATTAGGAGTTTTTCAGCAGAGAAGGGACATAGTACGACTTGGGTTTAA CAGGCTGGTTCTGGCTGCAAGCTCTGAAGCCCCAGTGATTTTTACTATTCTGAAAAGAAA CACTATGTCCAAGCATGCAAGCCCAAGAGTTAGGAACTACAGCATCTCTCTTGCTGACTG GGTCTCTGGTGTACATAGTCCCAGTCTTCAGAAACAGTCAGGGCCTCTTCTGAAAAACTT GAATGGCCAAGGACCTGTGTTCACCTACTTGCGTCTTCCTGGTACAGGTCCAGTTGGCTC CAGGTCACTGTGGTCATGGAGAGTAAGTTCCTAACTCAAAGGCCTGAGCAGGGCTGCTCT TTGGCACCAGCCTGGAGTTGTTAGTATGTGGTGACTATGTCAGAGGCACTTGGAAGATGG GAACCATGTTTCTCCTATAAGGACAGTGTGGCCTCTGTCCCTATCCTTGTTCACGCTGCA TATCTGTAGTAGACATAATATGTAGCCAGCCTTCCTGGTGAAGAGGCTAGTTCCCTCTTG TGGGGGCAGTAGGCACTGACATGCCTGTAAATGTGTCTGGAAATGTCTCTTCCTCTGAAA CCAGTAGGGCTGGTTTGGCCGTTCAGGGAGTGACATACTCTGGGACTACTGGGGGACTGC AGGTGCTCCACCCAGTCAGTGACTCTCCCTGCTCTCTCCTCCAGACAAGCAGATCGACCT GAGCACAGTGGACCTGAAGAAGCTCCGAGTTAAAGAGCTGAAGAAGATTCTGGATGACTG GGGGGAGACATGCAAAGGCTGTGCAGAAAAGTCTGACTACATCCGGAAGATAAATGAACT GATGCCTAAATATGCCCCCAAGGCAGCCAGTGCACGGACCGATTTGTAGTCTGCTCAATC TCTGTTGCACCTGAGGGGGAAAAAACAGTTCAACTGCTTACTCCCAAAACAGCCTTTTTG TAATTTATTTTTTAAGTGGGCTCCTGACAATACTGTATCAGATGTGAAGCCTGGAGCTTT CCTGATGATGCTGGCCCTACAGTACCCCCATGAGGGGATTCCCTTCCTTCTGTTGCTGGT GTACTCTAGGACTTCAAAGTGTGTCTGGGATTTTTTTATTAAAGAAAAAAAATTTCTAGC TGTCCTTGCAGAATTATAGTGAATACCAAAATGGGGTTTTGCCCCAGGAGGCTCCTA OMIM ID 601916