Entrez gene ID | | 79092 |
Official gene symbol | | CARD14 |
Full name | | caspase recruitment domain family, member 14 |
Aliases | | ,BIMP2,CARMA2, |
Gene summary | | The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q25 |
Gene position | | 78152281 - 78182851 Map Viewer |
Gene orientation | | plus |
Gene size | | 30571 bp |
Gene sequence |
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OMIM ID | | 607211 |
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