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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CARD14 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID79092
Official gene symbolCARD14
Full namecaspase recruitment domain family, member 14
Aliases,BIMP2,CARMA2,
Gene summaryThe protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q25
Gene position78152281 - 78182851  Map Viewer
Gene orientationplus
Gene size30571 bp
Gene sequence
OMIM ID607211