Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MANEA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID79694
Official gene symbolMANEA
Full namemannosidase, endo-alpha
Aliases,DKFZp686D20120,ENDO,FLJ12838,hEndo,
Gene summaryN-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM]
LocationChromosome: 6   Locus: 6q16.1
Gene position96025413 - 96057326  Map Viewer
Gene orientationplus
Gene size31914 bp
Gene sequence
OMIM ID612327