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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PDZD3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 79849 Official gene symbol PDZD3 Full name PDZ domain containing 3 Aliases ,FLJ22756,IKEPP,NHERF4,PDZK2, Gene summary Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM] Location Chromosome: 11   Locus: 11q23.3 Gene position 119056166 - 119060932  Map Viewer Gene orientation plus Gene size 4767 bp Gene sequence >PDZD3:22618582..22623348:Length=4767 CTTGTCCCTACCCCGGGCACTGGGTTGCTGATCCAGCTATGGAGAAAGCCGCAGGTAGGA GGCCAGGAGAAATCCTCTGCAGGGGACTTTGGGACAGGCAGGGGGCCGACTTGGAGGCTG AAGCTTTGGGACCAGGGCACACTTGATTTTGGGGCTTGGAGCCCTGAGGCAGGTAAACAA GTCAGGAGAAAAGTAATGAGTTGATATGTCTGTCTTCCTGGTCCACACCCTGTACTGATA TGCTCAGATTTATGTGCCAAGGACTTGGGGGGAGAGAAAGGGAGGGGACCGCACAATAGT CCTGTGTGTATGGCAGTGAGAAGAGAAGACCCCTTTGGAGCAGAAAGGAGGGGGCATGCC CTGAGTTTGGGGGTTTCCCTGAGTCCTTTTAGTTTATGCCAATGGAAGAGGCACATCTGG GGAGAAGAATGTGACTCTCCTCCTCTCACCCACTTCTTTGCCCAGTAGATCTGCAGGACA CAGCCTCGTTAACTCTGTAAGTGCCACGAGGGTTGGGGCAAGGGGAGGAAATAATTGGAG GCAGCGAAGCGCTTCACTGCCATTAGCACCTAAAGGAGATCCTGGGACCCAAGTCCAGCT GCCAGCTTGTACCTGCTTCCCCTGCCTCCTTGCAGGAAGTTTAAGTTTAACCCAAAGCTG GGCATTGATAATCCTGTCCTCTCCCTGGCCGAAGACCACGACCCCTATGGTAACTCCCTC ACCCCCTGGCAACCATTCCCTATCCCTGGAGGCACCACGGCTCCACACGGCCTCCGATCT CCTTGGTAACCACTCACTCGGTCTCCCTCTGATAACAGCCTTGGTTGGGAGTAGAGATAG GAGGGGCCGGGTGTTTTCTCCTGTCCCAGTCCCTCTGCCCACGAACCCCACCACCCAACA CCCAACCAGGCAGAAACTGCCCAGCACCCTATCAGGACACAGGGTCTGCCAGGCACACGG CGAACCTGTACTTGGGCTGTGCCCTCTCCTCCCCCTTTTCTGCTGCCCACCTCACCCTCC AGATCCCTGGAGCCTGGAGCGGCCTCGCTTCTGTTTACTGAGCAAAGAGGAGGGCAAGAG TTTTGGCTTCCACCTGCAGCAGGAGCTGGGCAGGGCTGGGCATGTGGTGTGCAGGGTGGA CCCAGGCACCTCTGCCCAGCGCCAGGGTCTTCAGGAAGGAGACAGGATCCTGGCGGTGAA CAATGATGTTGTGGAACACGAAGACTATGCGGTGGTAAGGCTGTGGTCCAGGAGAGCATG CTAGCACCTCAGAAAGAGAAGCGGGTTGCTCAGTCCCCTGGGCAGTATGGCAGCAGGGCA CAAGCCTCACTCCCCCACACCCCAGGATTTAGAAGTGCCCAAGTCAGAGGGGTAGGGAAA GCATCTAGAAAGCCGATTCCCGCTGGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTT GGGAGGCCAAGGCAGGTGGATCACCCAAGGTCAGGAGTTCAAGACCAGCCTGGCCAACAT GGCAAGACCCTGTCTCTACTAAAAATACAGAAATTAGCTGGGCGTGGTGGCAGGCGCCTG TAATCCCAGCTACTCGGGAGGGCTGAGGCAGGAGAATCACTTGAACATGGGAGGCGGAGG TTGCGGTGAGCTGAGATCGCACCATTGCACTCCAACCTGGGCGACAAGAGCAAAACTCCA TCTCAAAAAAAAAAAAAAAAAAGAAAAAGAAAAAAAGCCGATTCCCTTGGCAAAAAAATG TGGATTCCAGGGAGGTCCTGGGGGTTGGCAAGAGGGTCTAGACCAAACCCACGCCCACGT GCCCTCTGTCCAGGTGGTACGCCGCATCCGGGCCAGCAGCCCTCGGGTGTTGCTGACAGT ATTGGCACGGCATGCACATGACGTGGCCCGAGCTCAGCTGGGAGAAGATGCCCACCTCTG TCCCACCCTAGGCCCAGGGGTCCGGCCCCGGCTGTGCCACATAGTGAAAGATGAGGGTGG TTTTGGCTTCAGTGTCACCCATGGTGAGCCCAGAGGGTGCGAGGGGGCGGCAAGGATGAG GGATCTCAGCCCCTGTTCAGGGCAGGCAGGAAACAGACTGGACCTTGCTTTTTTTTTTAA TTTCTAGGCAATCAGGGTCCTTTCTGGTTGGTGCTAAGTACTGGAGGAGCAGCTGAGCGG GCAGGGGTGCCCCCCGGGGCCCGGCTGCTGGAAGTGAATGGGGTCAGTGTGGAGAAGTTC ACTCACAACCAACTCACCAGGAAGGTGTGACTGCCTGTCTCCCACTCTCCTCCCCCAATC CGGGCCTGGGCCCCACCTCGGGAAGACGCCTCCTTCCCCATGCGCCTAACCTCCTTATCT GGTCTCCTACCTTTATCACCATCCTCCCCCTCTACAGTTTGTGCCAGGCTCCACTTAGTG CCTGGGAGGAGGGGCTGTGGGGGGAGCATACCTCTTCTCTCCCTGCCCAGGTGTTATACT GATGCCCTGCTGGGTCCCCACAGCTTTGGCAGAGTGGACAGCAGGTGACCTTGCTGGTGG CAGGGCCAGAGGTGGAAGAACAGTGTCGCCAGCTGGGATTGCCCCTGGCTGCACCCCTGG CAGAGGGCTGGGCACTGCCCACCAAGCCCCGCTGCCTGCACCTGGAGAAAGGGCCCCAGG GTTTTGGGTTCCTGCTCCGGGAGGAAAAGGGCCTTGACGGTCGCCCTGGTGAGTGGGAGC CCTGGGGGCGGTGGGGGAAGGTGGGCCTTGGGGTGGGCACACAAGCGTATATACACCTTT CAGTGCACCGAAGAGGTGTCCCTGTCTGAGCTCTGGCCCTGGGCCGCCTCTTCCCGTTCA CTCTGGGGTCAGTCCCCTGGTGTGTACACAGTGGCCTAGGATAGCTGGAGAGGAGCAGTG AGGATGTCTATGCCCCAGGACAGTTCCTGTGGGAGGTGGACCCGGGACTGCCAGCCAAGA AGGCTGGGATGCAGGCTGGGGACCGGCTGGTGGCTGTGGCTGGGGAGAGCGTGGAGGGGC TGGGCCATGAGGAGACAGTGTCCAGGATCCAGGGGCAGGGCTCCTGTGTCTCCCTCACTG TCGTCGACCCTGAGGCGGACCGCTTCTTCAGCATGGTGCGTGCTGAGGGGCAGGGGCTAG GGTTGGGGCAGGAGTGGGGCAGGGCTGAGGTCCGAAAGATTTGCTCTCCCTGCCACCTTC CAGGTTCGCCTGTCCCCACTCCTCTTCTTGGAGAACACAGAGGCTCCCGCCTCGCCCCGG GGCAGCAGCTCAGCCTCACTGGTTGAGACAGAGGACCCTTCACTTGAAGACACAAGCGTG CCTTCTGTCCCTCTTGGCTCCCGACAGTGCTTCCTGTACCCTGGGCCTGGTGGCAGCTAT GGCTTCCGACTCAGTTGTGTGGCCAGTGGGCCTCGTCTCTTCATCTCCCAGGTGACTGAT GCCCCATGGATCTTGAATCCCTTCGATCCTTTGCTGCCTGATCGGTCTTCCTCTGCTTCC CTCCCAGAGCCTAAAGCCAGCAAACTTTCCCCCGGTGTCCCCTGTTCTGCATGCCCCCAC AACACCAGGTGACTCCAGGAGGCTCAGCTGCCCGGGCTGGGCTGCAAGTGGGAGACGTGA TTCTGGAAGTGAACGGGTATCCTGTTGGGGGACAGAATGACCTGGAGAGGCTTCAGCAGC TGCCTGAGGCTGAGCCACCCCTCTGCCTGAAGCTGGCAGCCAGGTCTCTGCGGGGCTTGG AAGCCTGGATTCCCCCTGGGGCTGCAGAGGTGAGGAAGAAGAAACAGATGGGACTGTGAG TAGCTACAGAGGGCAGGGAGGAGTGAGAAAGAAGGGCAGAGTGGGCGAGGTACAAGGTGA AGCCGTGTGGGGTATGCAGGTTGGGACTTCAGGTCGTGGTAGGTGGGGACAGAAGGACTC GTGAAATAAACCCCATTTCTGGGCATTCCAGTGCAGGGCGGGGCAAGAAAAAGGAACTCT TCTGGGTCCCACCTGGAATGACCTTCTACCTCCTCTCTCTGTATAGGACTGGGCTCTGGC CTCGGATCTACTGTAGAGCACCCCTGCTTGGTACAGACATACTCAGGGGCTACCGTGTCT TCACTCTCCAGCCTGAGGTGGTGAAGGCAGGATGCTCTCTCTAAGCCAGACCAGAGGGAC TCAGACACCACCGATCACAGGCTGGCCCAGGTGCTCCCTCCCTTCCTGCAGGCCCACCTG CCAGCAGAGGGTGTGGTTGGAGGCCTCAGACAGGTCCCTGAAGGAGTCTGAGGCTCCAGA GGATGTCATATGGGAGTTTTAGAGAGCTGTGTCCCAAGGATGAAGGTGTGGCTGTGGGTC TGGCTAGGATTGAAGCCATCTGGACCTTTTCTAGATATGACTCCAGGACCCTTGAGTGTA ATGCAAAAATTTGGAGACCAGCTATGCCTGCCCTCTGTGGGTGCCTTAGCATTGCGGGAG GGTGGTGCTTGGTCACCGTTGCATTTGTTATAGAAATGGCCATTCGCCATAAATCTGACT GCCTGTGTTTGTGTTGGTGGGGGTAAGGGGCAGTGGTGTGAAGGGACCAAAAGGGCCTCA GGCTCAAGGGGTGGGATGCGGCTCCTGCAGGAGAGAGGTTGAGACCTGGTCAAATTTATT TCCTATCAATCACTGAATCTCAGGGATAATGGGTCAACCCAGAACTGAGATGTCTGTATG ACAGCCACTCCTAAAAATAAACAACAACAAAAACAAAAAAAGAAGAAAACTAAATAAAAA TAAAAATAAAAATAAGATCCACTTCTC OMIM ID 607146