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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for STAM (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8027
Official gene symbolSTAM
Full namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases,DKFZp686J2352,STAM1,
Gene summaryThis gene was identified by the rapid tyrosine-phosphorylation of its product in response to cytokine stimulation. The encoded protein contains a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. HGS/HRS (hepatocyte grwoth factor-regulated tyrosine kinase substrate) has been found to bind and counteract the function of this protein. [provided by RefSeq]
LocationChromosome: 10   Locus: 10p14-p13
Gene position17686124 - 17757907  Map Viewer
Gene orientationplus
Gene size71784 bp
Gene sequence
OMIM ID601899