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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTP4A2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8073
Official gene symbolPTP4A2
Full nameprotein tyrosine phosphatase type IVA, member 2
Aliases,HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP4A,PTPCAAX2,ptp-IV1a,ptp-IV1b,
Gene summaryThe protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p35
Gene position32403988 - 32372022  Map Viewer
Gene orientationminus
Gene size31967 bp
Gene sequence
OMIM ID601584