Entrez gene ID | | 8073 |
Official gene symbol | | PTP4A2 |
Full name | | protein tyrosine phosphatase type IVA, member 2 |
Aliases | | ,HH13,HH7-2,HU-PP-1,OV-1,PRL-2,PRL2,PTP4A,PTPCAAX2,ptp-IV1a,ptp-IV1b, |
Gene summary | | The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p35 |
Gene position | | 32403988 - 32372022 Map Viewer |
Gene orientation | | minus |
Gene size | | 31967 bp |
Gene sequence |
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OMIM ID | | 601584 |
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