Entrez gene ID | | 8078 |
Official gene symbol | | USP5 |
Full name | | ubiquitin specific peptidase 5 (isopeptidase T) |
Aliases | | ,ISOT, |
Gene summary | | Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM] |
Location | | Chromosome: 12 Locus: 12p13 |
Gene position | | 6961285 - 6975796 Map Viewer |
Gene orientation | | plus |
Gene size | | 14512 bp |
Gene sequence |
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OMIM ID | | 601447 |
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