Entrez gene ID | | 8115 |
Official gene symbol | | TCL1A |
Full name | | T-cell leukemia/lymphoma 1A |
Aliases | | ,TCL1, |
Gene summary | | Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM] |
Location | | Chromosome: 14 Locus: 14q32.1 |
Gene position | | 96180533 - 96176304 Map Viewer |
Gene orientation | | minus |
Gene size | | 4230 bp |
Gene sequence |
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OMIM ID | | 186960 |
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