Entrez gene ID | | 81792 |
Official gene symbol | | ADAMTS12 |
Full name | | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | | ,PRO4389, |
Gene summary | | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q35 |
Gene position | | 33892124 - 33527286 Map Viewer |
Gene orientation | | minus |
Gene size | | 364839 bp |
Gene sequence |
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OMIM ID | | 606184 |
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