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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SPACA1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID81833
Official gene symbolSPACA1
Full namesperm acrosome associated 1
Aliases,MGC32952,SAMP32,
Gene summaryThe correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq]
LocationChromosome: 6   Locus: 6q15
Gene position88757507 - 88776550  Map Viewer
Gene orientationplus
Gene size19044 bp
Gene sequence
OMIM ID612739