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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CAMLG (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID819
Official gene symbolCAMLG
Full namecalcium modulating ligand
Aliases,CAML,MGC163197,
Gene summaryThe immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q23
Gene position134074206 - 134087847  Map Viewer
Gene orientationplus
Gene size13642 bp
Gene sequence
OMIM ID601118