Entrez gene ID | | 819 |
Official gene symbol | | CAMLG |
Full name | | calcium modulating ligand |
Aliases | | ,CAML,MGC163197, |
Gene summary | | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q23 |
Gene position | | 134074206 - 134087847 Map Viewer |
Gene orientation | | plus |
Gene size | | 13642 bp |
Gene sequence |
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OMIM ID | | 601118 |
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