Entrez gene ID | | 831 |
Official gene symbol | | CAST |
Full name | | calpastatin |
Aliases | | ,BS-17,MGC9402, |
Gene summary | | The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q15 |
Gene position | | 95997741 - 96110387 Map Viewer |
Gene orientation | | plus |
Gene size | | 112647 bp |
Gene sequence |
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OMIM ID | | 114090 |
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