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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CAST (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID831
Official gene symbolCAST
Full namecalpastatin
Aliases,BS-17,MGC9402,
Gene summaryThe protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q15
Gene position95997741 - 96110387  Map Viewer
Gene orientationplus
Gene size112647 bp
Gene sequence
OMIM ID114090