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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for AXIN2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8313
Official gene symbolAXIN2
Full nameaxin 2
Aliases,AXIL,DKFZp781B0869,MGC10366,MGC126582,
Gene summaryThe Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q23-q24
Gene position63557740 - 63524681  Map Viewer
Gene orientationminus
Gene size33060 bp
Gene sequence
OMIM ID604025