Entrez gene ID | | 8313 |
Official gene symbol | | AXIN2 |
Full name | | axin 2 |
Aliases | | ,AXIL,DKFZp781B0869,MGC10366,MGC126582, |
Gene summary | | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q23-q24 |
Gene position | | 63557740 - 63524681 Map Viewer |
Gene orientation | | minus |
Gene size | | 33060 bp |
Gene sequence |
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OMIM ID | | 604025 |
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