Entrez gene ID | | 8323 |
Official gene symbol | | FZD6 |
Full name | | frizzled homolog 6 (Drosophila) |
Aliases | | ,FZ6,HFZ6, |
Gene summary | | This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8q22.3-q23.1 |
Gene position | | 104310661 - 104345094 Map Viewer |
Gene orientation | | plus |
Gene size | | 34434 bp |
Gene sequence |
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OMIM ID | | 603409 |
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