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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FZD6 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8323
Official gene symbolFZD6
Full namefrizzled homolog 6 (Drosophila)
Aliases,FZ6,HFZ6,
Gene summaryThis gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q22.3-q23.1
Gene position104310661 - 104345094  Map Viewer
Gene orientationplus
Gene size34434 bp
Gene sequence
OMIM ID603409