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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CASP4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID837
Official gene symbolCASP4
Full namecaspase 4, apoptosis-related cysteine peptidase
Aliases,ICE(rel)II,ICEREL-II,ICH-2,Mih1/TX,TX,
Gene summaryThis gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q22.2-q22.3
Gene position104839325 - 104813594  Map Viewer
Gene orientationminus
Gene size25732 bp
Gene sequence
OMIM ID602664