Entrez gene ID | | 837 |
Official gene symbol | | CASP4 |
Full name | | caspase 4, apoptosis-related cysteine peptidase |
Aliases | | ,ICE(rel)II,ICEREL-II,ICH-2,Mih1/TX,TX, |
Gene summary | | This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q22.2-q22.3 |
Gene position | | 104839325 - 104813594 Map Viewer |
Gene orientation | | minus |
Gene size | | 25732 bp |
Gene sequence |
| |
OMIM ID | | 602664 |