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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CASP5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID838
Official gene symbolCASP5
Full namecaspase 5, apoptosis-related cysteine peptidase
Aliases,ICE(rel)III,ICEREL-III,ICH-3,MGC141966,
Gene summaryThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q22.2-q22.3
Gene position104893895 - 104864967  Map Viewer
Gene orientationminus
Gene size28929 bp
Gene sequence
OMIM ID602665