Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CASP6 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID839
Official gene symbolCASP6
Full namecaspase 6, apoptosis-related cysteine peptidase
Aliases,MCH2,
Gene summaryThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q25
Gene position110624629 - 110609785  Map Viewer
Gene orientationminus
Gene size14845 bp
Gene sequence
OMIM ID601532