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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPP1R1B (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 84152 Official gene symbol PPP1R1B Full name protein phosphatase 1, regulatory (inhibitor) subunit 1B Aliases ,DARPP-32,DARPP32,FLJ20940, Gene summary Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM] Location Chromosome: 17   Locus: 17q12 Gene position 37783179 - 37792878  Map Viewer Gene orientation plus Gene size 9700 bp Gene sequence >PPP1R1B:3057331..3067030:Length=9700 AGCTGGGACCGGAGGGTGAGCCCGGCAGAGGCAGAGACACACGCGGAGAGGAGGAGAGGC TGAGGGAGGGAGGTGGAGAAGGACGGGAGAGGCAGAGAGAGGAGACACGCAGAGACACTC AGGAGGGGAGAGACACCGAGACGCAGAGACACTCAGGAGGGGAGAGACACCGAGACGCAG AGACACCCAGGCCGGGGAGCGCGAGGGAGCGAGGCACAGACCTGGCTCAGCGAGCGCGGG GGGCGAGCCCCGAGTCCCGAGAGCCTGGGGGCGCGCCCAGCCCGGGCGCCGACCCTCCTC CCGCTCCCGCGCCCTCCCCTCGGCGGGCACGGTATTTTTATCCGTGCGCGAACAGCCCTC CTCCTCCTCTCGCCGCACAGCCCGCCGCCTGCGCGGGGGAGCCCAGCACAGACCGCCGCC GGGACCCCGAGTCGCGCACCCCAGCCCCACCGCCCACCCCGCGCGCCATGGACCCCAAGG ACCGCAAGAAGATCCAGTTCTCGGTGCCCGCGCCCCCTAGCCAGCTCGACCCCCGCCAGG TGGAGATGGTAAGGGGCCCGTGCCCCACCCCGGCAGCGTACCCGACACACCCCGCGGGGC TTCTTCGCCCTCCCAAGGCGCTGCCCCGGCCGGACTGGCCTGGGGGTGGGGGCGCAAGGA GAGCCGGGCTCTGCCTCGGTCAGGACGGGGCGCGGGGCCGCGTGTGAAGTTAGCTGGAGA CTCGTGCAACTTTTCCCCGCGGCTTTGGTCCTGATCCCGGGGCAAGAGAGTTCCTGGCAG TGAGGCTGGGGGTGCGGGGGTGGGGGGACAGGCCGATTCCAGACCGCCCAGGAGTGGGGT GGGGGCGTCCTTTGGTCCCAGCACAGTCCCCAAAGGGTAGTCAGTCTCCTAGGCTACCAC CGGGACCGCTCCGCCTGGCTCTGTCCCAGAGCTGGTCAGATGTGAGCAGCGGTGGACACT GACCTTGTCACCCAGGGCAGGAGTATGAGGCTGCCACCGGGTGAATCCACTACCCTGCCC CTCTCTAATCCCGCGTGTGTGCCTGGGCTGGGGTCTCCAGAACCTGGCTCTGGCCTCCTG CTGTCAGGCCCCAGAGCCCCAACCCCAAGGAGGGAGAGGTGGGGAGTCATCACAAAGCCA GACCTCTTCCCACAGACTACTGAGTCCTCCTGAGGGCCTTCTTGGGGGTTGAGGGGCTTC CAAAGGCTGGCGGGTGCTGTGACAGAGAGCTCCACTTCCCATCCCTAGTGGAGCAGGGGT CACTTGTTGCTGAGCTGAGATGCAGCTGGCTCCCCACTGAGCAGTGATGAGGGGGCCAAG TCATTATGGGGGGAGATAGAGGGCAGGGGGTACAGTCCTGGGCCTAAGCAGCTTTGGGTC ATGAGGGTGTCATGGGGAGCTTGGCTGGGGAGGTGGCAGTTTCAGCTTAACTCACCTGGT TCTCTTTGTGCATTTCCCTGGAGCTCAACAGGGACCTAATTAACTGACAGTTGGTCTGAT TGCCAAGCTGAGGGGCGGGGCGGGGAGGGGGGCGGTCAGTTGCTGCTTGGCTCACGTAGC AAGGAGGGCAACTTTTCATTTCTCACAAGGACTGGGTGAAGAGTTCTGCAGCCTTACAGA GACTGGAAAAGAAGCCCAAACCAAGGCCCCCAGAGAGGTCCCCCAGGCCCCTTTGGGTCC CTGAGCCTCAGCTGGAGGTGGGGGGTGCCTGCAGTGCGCTGGCTCAGTCTCCTTCTGAAA AGCTGGATCCAGCTTGTTTGAAGCCCTTGAGCTGATCTTAGGTGGGCAGGGCCACATGGG TGCCATGGCCCGTGGGGCATCTTCCCCAGAGGGCCCAGCCGTGGCAGCTGGAGCTGTAGC CAGCTTTGGCTTCCGAGGTCTGATGTTTTCAGAAACTGGAGAGAGGAAGGGCCTTGGTGG GAGAAGATAGGAAGGGAGATGTCTGTTCTGGAGTAGCCATGGAGTGGGACAGGCATGGGC TGGGAGTCAGTGACTGGGGTTTTTCTCGTCCTTTGGACTTGTTGTGCTGTGTGGCCTTAA GCACATTGCCAAATCTCTCTGAGCCCTGCTTTTTCACCTCTGTAAAATGAGGGGGTTAGG TGAGCTACAGAGTTCCTTTTGGCTCTGACAGACTTTGATTCAAAGGTTCCCTGGGGACTC CAAAGCACTGTTTGTTCCCTGCTGCCTGGGGGTGGGGGAGGGCTGCAGGTGTCCATCCAG TCACCCCTCCCTCCATCTCCTTAGATCCGGCGCAGGAGACCAACGCCTGCCATGCTGTTC CGGCTCTCAGAGCACTCCTCACCAGGTAGGCCCCTCCCTGCCCACTTAGCCCTGGCCCCA CCCTAGCTCTGATGCCTTCCTAGGGGCCCTGCCAAAGTCCCATGAACAGGAGTCAAAGCT GGAGACTGGGGAGTGGATAAGGTCTGGGAACCCAACTCTATTGGCTTTATTTATTGACAT GACACCTCCCAGCCGCAGGAGGGAGAGGGCACACTTTCCCTGTCCCCAGAGATTGAGACC CTGGGGAAAATAACTCGGATTCTTTCTCTCTCTCCCTCTTCTCTTTTCCTCCTCGCTTGG TTCTGGTTCGGTTGGCTTTGGTGGCCTTCCTCAGAGGAGGAAGCCTCCCCCCACCAGGTG AGTTTCCTGGGGCAGCTGGAAGGAGGGATGCCTGGGCCCCTTGGGGTGGGGTGGACGGGT GCCTGCAGTGACAACCAACCAGTATGGGGTGCCACCCAAGAGGACACATTAGCATATCAA TGGGCAGTCCTCTGAGAGTGCCTCATGCCAGGGTGCCACCAGCAGATCCTCCTCTGCTCA GACTCAGGGTGGAACCTCCTGGACCTAGAGTCCTGCCCTGAACCAGGCCATGGCTTATGG GGGGCCCCCCCTAAAGCCACAGGGTGGGGAGGCTCAGCCTAGGTGCAGGACCCATTAGCA GTGGCTAAATCAGTCTGCTTGGGTGGCCATGGGTGGGATGGAATGGAGGGATGGTGAAGG CAAGGGCCTCTGCTGAGCCCCTTTAACCTGGCACTTCCCCTGGCAGAGAGCCTCAGGAGA GGGGCACCATCTCAAGTCGAAGAGACCCAACCCCTGTGCCTACACACCACCTTCGCTGAA AGGTACTATACCCCCACCGACCTTCCTGGCTGTCCGCCTGATCCCTGGAACTGGGCAGAC GCTAGGGGAGCTTTTGTCAGTGGGGAGGGATTGTTTCGCCACACATAGCCCGCTGTCAGC GTGGCGCAACAACCCAACGTAAAGACCAATTTTTTCTCAGTCTGGCCTTGCAAAACACAG GAGTCCCGAGGCTGCAATGGGCAGCTATGGGCCTTAACATCGGGTTGTGGGCTTGAAAGA AAAGAGATGGCTGGCCTAAGACAACCAGCAGGCATCCGCGTGGAAGGGACTCCACCTGCA GCTCCTCTTCACCAGCCTGTGGTGGACCACCTCCCACCCCTGCTCATCCAGGGCGCCTTC TCCTGTGGGCTTCACCCCTGGCCTCCCCTCCCATTTGCATCCCATTTGCACAGATCTGCA CACTGGTCTCCTCTTTCCTGCTTCCCTTTCTCCATGGAAAAGCAAGCCATTCCTTTTGCA CACTTACTCAACACCTAGTATATGCCAGGCCAAGTTGGTGGGCATTGGGCAGAATAAGAT GAGTCAGATTTGGTCCCTGCCCCCTTGGGGCTCTTTGCCTCAAAGGGTCAGGGAGGGGCC AAGTAAGGTGGCTCACACCTGAAATCCCAGCACTTTGGGAGGCCAAGGCGGGAGGACTGC TTGAGCCTAGGAGTTCGAGACCAGCTTGGGCAATACAGTGAGACCCCCATCTCTATGAAA AATTTACAAAGTGAGCTAAGCGGGCCGGGCGCAGTGACTCACGCCTGTAATCCCAGCACT TTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAAC ATGGAGAAATCCTGTCTCTATTAAAAATACAAAATTAGCCAGGCGTGGTAGCGCATGCCT GTCATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCGGGAGGCAGAGG TTGTGGTGAGCTGAGATCGCACCATTGCACTCCAGTCTGGGCAAAAAGAGCAAAACTCTG TCTCAAGAAAAAAAAAAAAGTGAGCTAAGCATAGAGGTGCACACCTATAGTCCCAGATAC TTGGGAGGCTAAGGCACAAGGATTGCTTGAGCCCAGAAGTTTGAGGCTGCAGTGAGCTAT GATCGCACCACTGTGCTCCAGTCTGGGCTACAGAGTGAGAGCCTGTCTCGGGAAAAAATA AAAAAAGAAAAGGGTCAAGGAAGGTACACAAAGATGTTTAAGCTTGGATTTGAAGGATCA TAGGAATTTAACAGGCAGGCAAGGGCATCCCAGGTCCAAGAAGAGGGAAGAAGGTGTGCA AAGAGAAAGAGATGCGAGTCAGAGGGGGACTTCTGGGCCAACCTGGAGGAGGCTTCGTTT CTAGTCAGGGAGCTGGGGAGATATACCTGAAGGACATAGGAGGGCCTCTTCCTGACTAAG CCCTGTTGCCTACCAACCCCCCACCTCAACTCCTGCCTGGGGCTCTTCCTGCCCGGCCAG CCCCCTCCGCTCCTGCGGAGGTTGGGAGGGAGAGCTACCGGAAGAGTATGCTGGGAAGTG GTTCGGGGGAGGGTTTAATAAGTTCCCAGCACCAGCCAAGGTCAACAGGTATACCTGTCA GCCCACTTGCCAGGGTTGGGAACAGAGAGGAGAGGCTGGGAAGGGAGGAGAGAAGGGAAG GGGTTATTTTGCTTTCCCCAGGACAGGAAAATGAAGGGTCAGAGCTGCAGCAAGTGGGCA GTGTGGCTCAGCACCTGGAAGGACCTCCCCACCTAGAGGGGTGTGTGGAAGGGCCCCAAA GCAGGCATGAGGGACAGAGTGTCATCTTCTCAGGAGAGAATTTAAGAAATCCCTCTCCCT CCCACCTTGGGCTGGGTAGGGAGAGGCTGGGTGGATGTGAGGGGAAGACCTGGCTCTTGA CTGCAAGCATGGGCGAACAGGCCAGGATGAAGATGTTAGGGCCAGGGTGCTACCATGCAC CGTGCAGTGGTCAAAATTGTGCACCCCCTCAACTGCCCCTTTAGGCCACATCTTAGGAGA GTCCAGGTGAGTAGAGGCAGGGAAGAGGAAAGGGATCAGGAGAGGGGTGGCCAGTCTGGG GCAAGGCTGGGGACCTTCCAACTGAAGAAGGAAGACTTGTGGTGGGGGGAGTTTGGGGCC CCACAGAGTGGGGCAGAGAAGGAGACAGCCTGGAAGGAGTGATGGGGAGACCCCAGAGAG CCCAGGAGGCATGAGGGAGGTGGGGGAAGCGAGGGAGGCTCACGGGGCACCAGCGCAAGC ACCGCACACACCTTCTGTTGTCACTGTGGCTCACGAAGTGAACTCTCCTCCCCCGCTGGG GGAGAAGGAAGCTGCCTGGGCTGCCACCTGCTCTCCTGCCTTACCTCCCCCCACAGCCCT CATGGATCCTTCTCTACCAGGAGGGCACTGTTTTGTAGGCTTCAGTCCTTTTGTGGGCAA GGGAAGGTGCCCGGCAGGGTTGGGGCTTGTCAGGGAAGAATCGAGGGCCCTAGAGAGAGG GGCACAGCACTAAGTCTTAGCTTGAGGGGTTGTGCTCCAAGGCTGGAGCTCTCACACTTG GCTCAAGATGAAGCTCTGCCGCGTCCCCAAGGTCAGGGTAGGGTGATTTATTGTGCTTTT ATTGCCTGGATAGCTTGCCCAGAGCCAGCAGGAGGTACTGGGCTGGGAGCTGGGGGCTGG GTGGGGCAGCGGGCACATACAAAGCACCCTCTGTGCCTGTCCCCGAGTTGGCAGGAGCAT AGCACCCTGCTCACTGTGCCGGAGGTTTCCAGCCTGGCCCTACCCCTCTGGGCCTTCTGA GGGGAGGGGCCACTGGCAGACCAAGAAGGAACTGCAGCAACTCCCCATTCCCCACCCCCA GCCCCTCCTCAGCATCTTGTCTGTGGCCTGTGAACTTTGTGTCGCATATGTTCTAAGATC CTGCCAGCTCCTGCAGCCTCTCCTCAGTGGCCCCTCAACCTCTGCCATCCCCCAGAACCC CTGGCCTTGGCCCCTTTCTCTAACCCCTTGCTCCTTTCCATCTTTTGGAAACTTGTCTCC AGCTGCCCACACTGTTCCCTTCCCAGCCCTATCTGAGCAGGTCTTTGGAGGCTGGGGGGG TTGCTTTCTAGGTCACCGCAGAGGGAGCTGGGAACCTGGGGATGTGGGTCAAGATTGTGG GGGCCGCATCTGAGCATGCCGCATCCCCCGGCACAGACTGCACTGGCTGCAGACTATTAT GTCCTCAGCCTCGGAATTGTTCTGTCCCTTGGAGCCCGGGGCAGGAGTATGTGGATTGGC ATCTATGACTGGGCAGTGCCAGGGAGTGGGGACTATGCATCGCATGGGAGGTAGGATCAG GGTAAGCAGTGAGCCCTCAGCAGGCTGGGCACCCCCAAGAAATGGAAAGTGGCAAATCCC CAGGCCCTGGTTCCTACGCCCTGTGCCTTCTGCCTGGGCTTGAAGCTGGGAGACACTGTC TCCCGTACTGGGTACTTGGAAAATCAAGCTCTCCAGCCAGGGAATGTTAAGCTGCTGCTG TGCCCGCCTGGTCTTGCCCAGCCTAGTGCCCTATGGTGTGGGGGAGCTGCCTGGGGGCTA GCATCTTAGGACAGCTTAAGAGCCAAACATGATCAAATCTACCCCTGGCTGCCTCTGCCC TGGTCTGACACCCATCAGGCTGACCTGTCAACTTTGGCCTTTGAACTTGGGCCCCTGAGG GGGTATTCTCTGCCCCAGGCCTACGGGAAGGAGGCTGGGGGCTAGGCCACAGGCTATCTC CAGATCCATGGGCTGTGTCTAGCTGACCCTTGCTTTCCTCGGTCTCCTCTGTGCCAGCTG TGCAGCGCATTGCTGAGTCTCACCTGCAGTCTATCAGCAATTTGAATGAGAACCAGGCCT CAGAGGAGGAGGATGAGCTGGGGGAGCTTCGGGAGCTGGGTTATCCAAGAGAGGAAGATG AGGAGGAAGAGGAGGATGATGAAGAAGAGGAAGAAGAAGAGGACAGCCAGGCTGAAGTCC TGAAGGTCATCAGGCAGTCTGGTAAGCTGAGGGGCCTGTGACATGTGGATTAGCTGTGGG TCCTCCTTGAGTATACGAGGACGTCCCCTTCTAGTTCAGTGTCTCATACACGCAAACTGT AGTGACACCACAGGGGCCTCCCTGTCTTCTCGCTCCATGGGGTGCCCCGAACTCAGCCCT ACCTGAGACATGGGTTTCCTCCATCCTTGGCTCAGTCCCTCTCCCAATCAGGTTTTCCCT AATAATTCCTCTCTTCCCTGAGAATTAAGGCCAAGGCCGTTTGGGGTTTGAGGCTAGAGC CAAAAGAGGACTTCCCACCTATGGCAGTAAGGGGGCGTGAGGACATTCAGGGATGGAGGA CCAGGAGAGTCCAACACCCCTGTCACCTGCATTTCACCTACATTTTTGAACCTAGGATGT GGTCTCTGCTGGGGTGCAGAGGGCTGCCTCATTTACTTGCCCTCTCCAGGACTGTTGTCT GTTTCTCCTCTTTTTCCTTCCTAGGATGGAGTGGGAGGGTGCCCTCTAGTGTTTAGATGT AGAATTTAAAATTCAAGAACCAGCCCGGCCCATTAACCTTTTTAGTCTCATTATTTATGG GAATACTGAAGAGTCAACCACCCCTACTAGAAGCTGTCAGCTCTTCCACACAAACAAAAG GCCTTGGGCCTCCTGCCTGCATATCTGGCAGTGAAGAGATTGGCCATGGGGGCAAAAGCT GTTGCTGGGCTTCAGTCCCTTTGTGGGCAAGAGACAGCTGGAAGACCTGAATCAGTCCTC ACTGAGACCCCTCCAAAACAGTGGAAGAGGGGTGAGAGGAGACTGTTCCCTCAGGAAAAG CAGCAGGTGGCTGGGTGCGGTGGCTCATGCCTGTAATTCCAGCACTTTGGGATGCCAAGG CTAGCGGATCACTTGAGGTCTGGAGTTCAAGACCAGTCCAGCCAACATGGTGAAACCCCA TCTGTAATAAAAATACAAAAATTAGCCAGGCACAGTGGCACACACCTGTAATCCCAGCTG CTTGGGAGGCTGAGGCAGAAGAATCCCCTGAACCTGGGAGGTGGAAGTTGCAGTGAGCTG AGATCGCACCACTGCACTCCAGCCTGGGCAACAGAGTGAGACTCCATCTCAAAAACAAAA ACAAAAAACCAAAACAAAACAACAAAAAAAAACAAACAAACAAAAAATGCAGAAGGGCAC CGGGTCAAATGATAGTCCTATGATGGAGCAATATAAACCACCACGACTCCTAGTGGCTCC TGGGTGCTGGCGCTGGGCTGGGCAGGGTATTCACTATTACATCTTGTTTAAGGTAATCTA CACAATTTCCCCCTTTCTATTTCCTTCAGAAAGGTACTAACTGACTTACGTAAGCCATAT GGCTAGTTGCTGGGAGAGCTGTTCTAGCCCAGTTCTCTCTCCATGCTTCCATGATGCCCC TGGAAAGCTTAACCTCAGCCATCAGACACTTAGCTCACACTCCAGGACAGCCGGATGGAT ACGCAGAGCCTGTGTTCTTATCTCTTCTTTCCCATCCCCAGCTGGGCAAAAGACAACCTG TGGCCAGGGTCTGGAAGGGCCCTGGGAGCGCCCACCCCCTCTGGATGAGTCCGAGAGAGA TGGAGGCTCTGAGGACCAAGTGGAAGACCCAGCACTAAGTGGTAAGGCTTGGGAGTGTGA AATGGGGAGGAGGGGCTGGGATCTTGGTGGGTGGGGCCAGGCCCTGAGTCCCTCTCTGCT TGCCTTTCAGAGCCTGGGGAGGAACCTCAGCGCCCTTCCCCCTCTGAGCCTGGCACATAG GCACCCAGCCTGCATCTCCCAGGAGGAAGTGGAGGGGACATCGCTGTTCCCCAGAAACCC ACTCTATCCTCACCCTGTTTTGTGCTCTTCCCCTCGCCTGCTAGGGCTGCGGCTTCTGAC TTCTAGAAGACTAAGGCTGGTCTGTGTTTGCTTGTTTGCCCACCTTTGGCTGATACCCAG AGAACCTGGGCACTTGCTGCCTGATGCCCACCCCTGCCAGTCATTCCTCCATTCACCCAG CGGGAGGTGGGATGTGAGACAGCCCACATTGGAAAATCCAGAAAACCGGGAACAGGGATT TGCCCTTCACAATTCTACTCCCCAGATCCTCTCCCCTGGACACAGGAGACCCACAGGGCA GGACCCTAAGATCTGGGGAAAGGAGGTCCTGAGAACCTTGAGGTACCCTTAGATCCTTTT CTACCCACTTTCCTATGGAGGATTCCAAGTCACCACTTCTCTCACCGGCTTCTACCAGGG TCCAGGACTAAGGCGTTTTTCTCCATAGCCTCAACATTTTGGGAATCTTCCCTTAATCAC CCTTGCTCCTCCTGGGTGCCTGGAAGATGGACTGGCAGAGACCTCTTTGTTGCGTTTTGT GCTTTGATGCCAGGAATGCCGCCTAGTTTATGTCCCCGGTGGGGCACACAGCGGGGGGCG CCAGGTTTTCCTTGTCCCCCAGCTGCTCTGCCCCTTTCCCCTTCTTCCCTGACTCCAGGC CTGAACCCCTCCCGTGCTGTAATAAATCTTTGTAAATAAC OMIM ID 604399