Entrez gene ID | | 84171 |
Official gene symbol | | LOXL4 |
Full name | | lysyl oxidase-like 4 |
Aliases | | ,FLJ21889,LOXC, |
Gene summary | | This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q24 |
Gene position | | 100028007 - 100007443 Map Viewer |
Gene orientation | | minus |
Gene size | | 20565 bp |
Gene sequence |
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OMIM ID | | 607318 |
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