Entrez gene ID | | 842 |
Official gene symbol | | CASP9 |
Full name | | caspase 9, apoptosis-related cysteine peptidase |
Aliases | | ,APAF-3,APAF3,CASPASE-9c,ICE-LAP6,MCH6, |
Gene summary | | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p36.3-p36.1 |
Gene position | | 15850790 - 15818791 Map Viewer |
Gene orientation | | minus |
Gene size | | 32000 bp |
Gene sequence |
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OMIM ID | | 602234 |