Entrez gene ID | | 8428 |
Official gene symbol | | STK24 |
Full name | | serine/threonine kinase 24 (STE20 homolog, yeast) |
Aliases | | ,MST3,MST3B,STE20,STK3, |
Gene summary | | The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM] |
Location | | Chromosome: 13 Locus: 13q31.2-q32.3 |
Gene position | | 99229396 - 99102455 Map Viewer |
Gene orientation | | minus |
Gene size | | 126942 bp |
Gene sequence |
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OMIM ID | | 604984 |
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