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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP11 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8446
Official gene symbolDUSP11
Full namedual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Aliases,PIR1,
Gene summaryThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq]
LocationChromosome: 2   Locus: 2p13.1
Gene position74007284 - 73989325  Map Viewer
Gene orientationminus
Gene size17960 bp
Gene sequence
OMIM ID603092