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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for GLIS2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 84662 Official gene symbol GLIS2 Full name GLIS family zinc finger 2 Aliases ,FLJ38247,NKL,NPHP7, Gene summary This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys. Location Chromosome: 16   Locus: 16p13.3 Gene position 4382225 - 4389598  Map Viewer Gene orientation plus Gene size 7374 bp Gene sequence >GLIS2:4322225..4329598:Length=7374 TGAAGACCAGCTGGGAGCCCACTGCCTGCTGCCACCTCCAACTCCGGCCCCCTCACCATG CACTCCCTGGACGAGCCGCTCGACCTGAAGCTGAGTATCACCAAGCTCCGGGCGGCAAGA GAGAAGCGGGAGAGGACGCTGGGTGTGGTCCGGCCCCGTGCTCTGCACAGGGAGCTGGGC CTGGTGGATGACAGCCCCACACCTGGCTCTCCAGGCTCCCCGCCCTCAGGTACTGGCCCT GGGCAGGGCAGGGGGACTTAGCCCTGATCCAGTCATGGTGACAGGGAGAATGGCCAAGTG TGTCCACCAGCATGTAGCTGCAGCCCCTCTCGGCTTCCGGTTCATGGGAAGCCCGCACGC TTGTCCTTCCATCCGCCCAGCATCGTATGTCTGCAGGGAGGTGGGAGCTGCAGTGCCCAG CTCACGTGGCTGGCACACGATGCAAACTGAGGCCTCTAGGCAGATCTGGAACAGAGCTGG TCGGGCAACCAGGCATTCAGAAGGAGCGGCAGTAGTCCCAGGACCTGCACCCTAGGCTGT GGGGTGGTGCCGCTGGCCAACCTGGGCAGTAGAGGCTGGGTCTGAGCCCAGGAGGTGCCT CTCAGGGATTCCCGGTGCTTGGGCCCAGGGTGGTGGGCACCACTTCTGCCCTGCCTCCAA GAGCAGAGTCACCCGAAAACCAGATTCACCGCTTGTCTGAAGGGGAAGGCTATGGGAGCA GCCCAGCCCGAACCTGCCACTTTACAGAAGGGAACACTGAGGCAGGAAGGGGCCTGGGAA AAGCTAGAAAGGTTCCTACCTGCCCGTCTGACAGGGACCCAGGGGCCCTGGGTTCGAGTC CTGTTCTGTTATTAACCCTGCGTGCCAGACCATTCCCGTCTGCAAAGCGGGCACTTCCCC CCTCCCCGGCTCACGGGGGCCAAGCTCTGGCGGCTGGTAAAGCTCAGAGGTGGTGGGTGG TGTCACACACCTGTCAGCTCCACAGGCTGCTCCTCACATTCGTGTGGTCTGGGGGCATGG CTGGTGTCTGCTCCCAAGGTCACAGTGGGGGTTCGGAGGCAGGAGTACCTGGCCCACTGG GACTCTACACTCCAGCACACCCTGAACTGTGCCTCTCCCTCAGGCTTCCTGCTGAACTCC AAGTTCCCCGAGAAGGTGGAGGGACGCTTTTCAGCAGCCCCTCTCGTGGACCTCAGCCTG TCACCACCATCTGGGCTGGACTCCCCCAATGGCAGCAGCTCGCTGTCCCCCGAGCGCCAG GGCAACGGGGACCTGCCTCCAGTGCCCAGTGCCTCGGTAAGGAGGGGTGAGAGTTCCGGA GAGAGGGGTGGACTGGTTTCCTGGGGTTGCCATGACAAAGTACCCCAACACTGAGTGGTT TAAAAAACAGATGTGTTACCCCTCATAATTCTGGAGGCTGGAGTCTACCTGGAAGGCTCT AGGGGAGAACCTTCCCTGCCTCTCTCCTGCCTTCTGGCAGCTTCTGGAAATGCCTGGCAC TCTAGCCTGGTAGCTGCTTCACTCCAGGCTCTGCCCTGTCTTCACACGGTCTTTGTCCCT CTGTGTCCGAATCTCTCTCTGGTTTCTCTTATAAAGACACCAGTCATGGCCGGGCACGGT GGCTCACACCTGTAACCCCAGCACTTTAGGAGGCTAAAGTGGGAAGATCGCTTGAGCCCA GGAGTTCAAAACTAGCCTGGGCAACATAGCAAGACCCCATCTCTATTTATTTTTTTGAGA CAGAGTCTTGCTTCATTGCCCAGGCTGGAGGCCAGTGGCCCGGATCTCAGCTCACTGCAA CCTCCGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGCTGGGACTACAGG TACACACCATCACACCTGGCTACTTTTGTATTTTTAGTAGAGACAGGGTTTCTCCATGTT GGTCAGGCTGGTCTTGAACTCCTGACCTCAACTGATCCGCCCATCTCGGCCTCCCAAAGT GCTGGGATTACAGGCGTGAGCCACTGTGCCCGGCCTTTTTTTTTTTTTTTTTTAAACAGG GTCTAGCTCTGTCACCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCT GCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAATAGCTGAGATTACAGGCA TGTGCCATCACGCCTGGCTAATTTTTGTATTTTTAGCAGACATGGGGTTTCACCATATTG GCCAGGCTGATCTTGAACTCCTGACGTCAAGTGATCCGCCCACCTCAGCCTCCCAAAGTG CTGAGATTACAGGCGTGAGCCACCGCACCTGGCTATATATTTTTTTTAATTAAGAAAATA AAAATTTAAAACACACCAGTCACTGGGTGTTGGGCCCACCCTAATCTAGTGTGACCTCAT GTTAACTTGATTACATCTGCAAAGATCCTAGTTCCAAATAAGGCCACATGCACAGGTAGG GGCTGGGGAGAAGAGGACCTGAATGTCTCTGTTTGGGGACACCATTCAGTCCACTACCGA TGGGACGGGGGGCTCTGGGCCAGCAGGACCTTGACTAGCCCTCCCCTCGCACCCCAGGAC TTCCAGCCACTGCGCTATTTGGATGGTGTCCCCAGCTCCTTCCAGTTCTTCCTGCCCCTC GGCTCCGGGGGGGCCCTGCACCTGCCTGCCTCCTCCTTCCTTACCCCTCCCAAGGACAAG TGCCTCTCGCCAGACCTGCCCCTGCCCAAGCAGCTGGTGTGTCGCTGGGCCAAGGTGAGT GGGGGCCAGCAAGAGTAGTGTGGAGTCTGGGGCAGGTCACCCCGCATGGGCTCAGAACAC TTCCCATCCTCCGCAGTGTAACCAGCTCTTTGAGCTCCTGCAAGACCTGGTGGACCATGT CAACGATTACCATGTCAAGCCCGAGAAGGATGCGGGGTACTGCTGCCACTGGGAGGGCTG CGCCCGCCATGGCCGAGGTTTCAACGCCAGGTGAGGTGGGGGAGAGAGGGGTAGAGGGAG GACTGGGGTCTCCAGTGAGCTGAGCCGTGCCCCCCGCCCTCCCTGGAGCAGGTACAAGAT GCTCATCCACATCCGCACACACACCAACGAGAAGCCACACCGCTGTCCGACCTGCAGCAA GAGCTTCTCCCGCCTGGAGAACCTGAAGATCCACAACCGGTCGCACACAGGTAAGAGGCC GGGGCCGGGCGGCTTGGCCCATGAAGGGGGCGCTCAGCTGAGACCGGCTGGGCAGGTCCC CAGGGGGAGGGGACTGTTAAGTAAATCCCGGGCCTCAGAGATAAGGGTTGATGTCATCGC CCAGGGGTCCCTTTTCCAATGCAGTTTGCTAGGGGAAGCATCCCCTGGGGGTCAGACCCC CACCCAGCACCTGCTCTTGGAGCACCAATGCCATTTCCTGGTTCCCGTGGGTATCTTCTG ACTAATGCCACCTCTGTGATCGCAGAGGCCAGGTCGGCTTCACTCCTCACTACAGCCCAG GCCCATACCAGGACAGCTCTGGTTGTCAGAGCCACAGACATAATTTTACATTTCCTAATC GCTGCATAAAACACAGCAAAAATAAATGGGTGAAATTAATTGTAATATGGTTCGTTGACC CCGGTACATCCAACGTGTTATCAATTCATTATTAAAGACAAATCAGTGAGATATTGAAGT TCTTCATTTCATGACAAAGCCTCAAGGAGCTGATGTGTATGTTTTTTCCTGGTGTTTATT TCACCCTGGCAGCACATCTCCAGGTGGAGAGCCATGTATCAGGAGGTCAGTCACTACATG TGGCCCCCTGCTCTGGCCAGGGCAGCAGAAGATGCCTGGTGAACCTTCAGCCATTTGTTG AGTGAGGGCAGTAGCGCCCAGGCAGCACTCCCTGTGGCCAGGCCCACGCTGGGCGCCTCG TGCCAGGATGTGATCTCCAAGGCCATGGTGTCTTTTTTTTCTTGAGACAGACTCACTCTG TCACCCAGGCTGGAGTGCAGTGGCATGATCTTGGCCCACTGCAACCTCTGCCTCCCAGGT TCAAGTGATTCTCCTGCCTCAGCCTCTGAGGTAGCTGGGATTACAGGCACCTGCCACCAC ACCCAGCTAGTTTTCGTAGTTTTAGTAGAGACGGGGTCTCACCATGTTGGCCCTGCTGGT CTGGAACTCCTGGCCTCAAGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGAAATTACA GGCGTGAGCCACCGGGCCCGGCCTCCAAGGCCATGTTCTGCTGCTGAAAGGCACATCCTC TGTAGCAGAGGGTGCAGGGCGAGGCTAGGCAGAGCTGGAGTCAACCAGGCTGAGTTTTCA GCCTCTGTGCCCTGCCTGGGGGCAGATCTCATGCCATGTGCTGGGGATGCCCCCTGCCCC CAGAATTGGGGCATCTATGTTCCCAGGGAGTGCTTGGCCCGGGGAAATGTTGAGTGCATG GGGTGAGACCCAGGAAGGGGAGAGACCCCTCATGGCGGCACTGCACTGCACCACCCTGCA GGTGAGAAGCCCTACGTCTGCCCCTACGAGGGCTGCAACAAGCGCTATTCCAACTCCAGT GACCGCTTTAAGCACACGCGCACCCACTATGTGGACAAGCCCTACTACTGCAAGATGCCC GGCTGCCACAAGCGCTACACGGACCCCAGCTCACTGCGCAAGCACATCAAGGCCCATGGC CACTTTGTGTCCCACGAGCAGCAAGAGCTCCTGCAGCTGCGCCCACCCCCCAAGCCGCCA CTGCCCGCCCCCGACGGCGGCCCCTATGTCAGTGGGGCCCAGATCATCATCCCCAACCCA GCTGCCCTCTTTGGAGGCCCTGGCCTGCCCGGCTTACCCCTACCCCTGGCCCCCGGCCCC CTTGACCTCAGTGCCCTGGCCTGTGGCAACGGTGGGGGCAGTGGGGGTGGGGGGGGCATG GGCCCTGGGCTGCCAGGCCCCGTCCTGCCTCTCAATCTGGCCAAGAACCCGCTGCTGCCC TCGCCCTTTGGGGCTGGCGGACTGGGCTTGCCTGTGGTCTCCCTCCTTGCTGGCGCAGCT GGTGGCAAGGCCGAGGGGGAGAAGGGGCGTGGGTCGGTGCCCACCAGGGCCCTGGGCATG GAGGGCCACAAGACGCCCCTTGAAAGGACGGAGAGCAGCTGCTCCCGGCCAAGCCCCGAT GGACTCCCCCTGCTGCCAGGCACCGTGCTGGACCTGTCCACGGGCGTCAACTCAGCTGCC AGCAGCCCAGAGGCGTTGGCCCCTGGCTGGGTGGTCATCCCGCCGGGCTCGGTGCTGCTC AAACCGGCTGTGGTGAACTGAGCCCATCCTGCGGACAGTTGTGGTGCCCCCCCGGCAGCT CCCGGCACTGCCCCCGACGAACGGAAACTCTTCTGTGAAATAGCAATAATGTCCTACTGC CCGGGCAGCCCCAGCCCAGCCCGCCGGGAGCAAGGATGGTGCTAGGTCATTCATGGCTGG CCTCCCAGCCCCCGGGTGGGGACCTGGCCTGTCATGCAGGGAGAGCTGTGCTCCTGGGTG CTGAAGCCTCGCTCCTGTCTGTCCCCCACCACCTGGCCCTCAGCTTCTGAGAGGCTTTCC CCTGCCCGACCTCCTCCCGTTTCCCTCTCCCACCCTGGCACCTCCCTCACCTAGTGACCA CCCATGGCAAGTTGCCCTCTCCCAGCAGAGGGGGTGGGTGGGGTGGCATCTGCCCTCCCT GCTAGCACCAGGCTCCCCCTTCCTGAGAGGAGCCCCCAGGGACCAGAGGCCTGCCCTTCC CTCCTAGGCTTACCCAGCCCCTGCCCTGGGGGCTCCTTGGACCCCTTTCCCTCTGACCCT GCCTCCAGAGGGAAAGCAAGACAGATGCAGGCCCCTGCAAAGCCCCAGGTAGAAGCATGC CCCCCAGGACAAGGCGCCTCCCACTAGTTAGGAGGAGGCCCGCTCTGCAGCCGCCGTCCT CACCCCAGGCCAGGCCTGCAGTACCAGACGGGATAGCTGGCCACTCCACCCCTGCACCCC AGGGTCTCCTCCCTCTACCTTTTGGGGCACCCTGGGAGCGTGGGAAGCAGGTCCGAGGGC CCCTGAGCTGGCAAGGGGAGGTGCCAGGCCAGCTGTGGTGCCAAGATACTGAGTGACCTG GGCCCTGGCTCAGGGAGCATGTGGGGCCAGGCCCAGCGCCCCGTCTTCCTCCTTCTACCC CCGCTGGGCCTGGCCTGGGCAGCGCCCCCTGCAGAGGCCTTTGGGTCCTTGGTCCTGTAA CAGGAAGGGGGAGGCTGGCTGGGGACGACCGACCACAGGCTGGGACACAGCTCCTGGTCT GGGGGCTCCAAGTGACAGCATGCAGGGGAGGGGGCTCCCAGTCAGTGCTGTGTTGGGAGC TTTCTGGAGGCTGTGGACTGAAGGCCTTGAGGGAAGCAGTGGCTGGAGGAGGGTGCTGGA CCCATGACACGTTGCTTCCTCTGGCTTTTCCCTGCTGGGCCGCTTTCTCAGAGGCACTTC CCCACCCCTAACACCCAGTGGGCCCCCCCAGGTTCTGTGCCACTCAGAGGGACCCTGGCA GGGGCCAGAACCACTTAAGGGTGGTGCTGGAGGGCCTTGTGCCCCAGTCCCATCCCAGGA CGCCCTGAGGGATGGACGCAGCCATGCACCCCCCATCTGGGGCCTCTCCCTGCTCCCTCT CCCACCTGGCAGCTGGGAGTTCTGGCTTCTAGGCCTGCCCTGTCACCAGGCCTCTGAGTG GCCAGGCCCTTCCACCTCCCCATCTGTAAAACGAGGCAGCTGCCCGGACAGCCTTGGGGT CCTTAGTGGCCCTGCAGGTCCTCTGGCAGCTCTGCTGACCCCACCCTCTCCCGGACTGCC CTTCTGTCCCAGAGGGGTCACCCTGACCCGGCCCACCTTGCCACTGGGCTTTGGACTCCA GCCCTGACAGGGCCCAGCCACACTGGCTCTGCCCCTCGAAGGGGCTATGAGCAAGGTAGG AGGGAGCTGGTCTCCTTTCTTCGGGCCCCACCCAGGCCCTGAGCACCCCCCACCCCTGTG AGGGCCCCAGGCCTTAAGTCCCTGGCGGGGTCATGGGTTTGCGACTTGAGCAGAGCGGAG GAACAGGGCACTGGAAGGCCGACGAGCTCAGCATGCGACTCGGTGACGGACCAGGCTCGG CAGGGCCGGTGTACTTTTTGTGGTTGTCATTGGTGTGTTGTTGCACATTCCAGGACGTCA GTATTTTAACAGGTTCTAAGTGCCTTTCTATCGTAGCTTATGTTTTCCTCCTCTTGGCTC CATTGCTGTTAGCATAGAGTTTTAAAAAAAGAGATAAGCTAATGACTATAACAATATATT CCTCCATGGGAGAGGAAGTTTATAAAGAAACAATAAAAGTGAGTTGCAAAGATG OMIM ID 608539