Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CAT (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID847
Official gene symbolCAT
Full namecatalase
Aliases,MGC138422,MGC138424,
Gene summaryThis gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p13
Gene position34460472 - 34493607  Map Viewer
Gene orientationplus
Gene size33136 bp
Gene sequence
OMIM ID115500