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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SORBS2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8470
Official gene symbolSORBS2
Full namesorbin and SH3 domain containing 2
Aliases,ARGBP2,FLJ93447,KIAA0777,PRO0618,
Gene summaryArg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]
LocationChromosome: 4   Locus: 4q35.1
Gene position186877870 - 186506598  Map Viewer
Gene orientationminus
Gene size371273 bp
Gene sequence