Entrez gene ID | | 84868 |
Official gene symbol | | HAVCR2 |
Full name | | hepatitis A virus cellular receptor 2 |
Aliases | | ,FLJ14428,KIM-3,TIM3,TIMD3,Tim-3, |
Gene summary | | CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM] |
Location | | Chromosome: 5 Locus: 5q33.3 |
Gene position | | 156536138 - 156512843 Map Viewer |
Gene orientation | | minus |
Gene size | | 23296 bp |
Gene sequence |
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OMIM ID | | 606652 |