Entrez gene ID | | 84893 |
Official gene symbol | | FBXO18 |
Full name | | F-box protein, helicase, 18 |
Aliases | | ,FBH1,FLJ14590,Fbx18,MGC131916,MGC141935,MGC141937, |
Gene summary | | This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10p15.1 |
Gene position | | 5932214 - 5979556 Map Viewer |
Gene orientation | | plus |
Gene size | | 47343 bp |
Gene sequence |
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OMIM ID | | 607222 |
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