Entrez gene ID | | 8491 |
Official gene symbol | | MAP4K3 |
Full name | | mitogen-activated protein kinase kinase kinase kinase 3 |
Aliases | | ,GLK,MAPKKKK3,MEKKK 3,RAB8IPL1, |
Gene summary | | This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p22.1 |
Gene position | | 39664219 - 39476422 Map Viewer |
Gene orientation | | minus |
Gene size | | 187798 bp |
Gene sequence |
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OMIM ID | | 604921 |