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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP4K3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8491
Official gene symbolMAP4K3
Full namemitogen-activated protein kinase kinase kinase kinase 3
Aliases,GLK,MAPKKKK3,MEKKK 3,RAB8IPL1,
Gene summaryThis gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3). [provided by RefSeq]
LocationChromosome: 2   Locus: 2p22.1
Gene position39664219 - 39476422  Map Viewer
Gene orientationminus
Gene size187798 bp
Gene sequence
OMIM ID604921