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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MADD (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8567
Official gene symbolMADD
Full nameMAP-kinase activating death domain
Aliases,DENN,FLJ35600,FLJ36300,IG20,KIAA0358,RAB3GEP,
Gene summaryTumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p11.2
Gene position47290927 - 47351582  Map Viewer
Gene orientationplus
Gene size60656 bp
Gene sequence
OMIM ID603584