Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CAV1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID857
Official gene symbolCAV1
Full namecaveolin 1, caveolae protein, 22kDa
Aliases,BSCL3,CGL3,MSTP085,VIP21,
Gene summaryThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
LocationChromosome: 7   Locus: 7q31.1
Gene position116164839 - 116201239  Map Viewer
Gene orientationplus
Gene size36401 bp
Gene sequence
OMIM ID601047