Entrez gene ID | | 862 |
Official gene symbol | | RUNX1T1 |
Full name | | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
Aliases | | ,AML1T1,CBFA2T1,CDR,ETO,MGC2796,MTG8,MTG8b,ZMYND2, |
Gene summary | | This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8q22 |
Gene position | | 93107443 - 92971152 Map Viewer |
Gene orientation | | minus |
Gene size | | 136292 bp |
Gene sequence |
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OMIM ID | | 133435 |
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