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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RUNX1T1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID862
Official gene symbolRUNX1T1
Full namerunt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Aliases,AML1T1,CBFA2T1,CDR,ETO,MGC2796,MTG8,MTG8b,ZMYND2,
Gene summaryThis gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
LocationChromosome: 8   Locus: 8q22
Gene position93107443 - 92971152  Map Viewer
Gene orientationminus
Gene size136292 bp
Gene sequence
OMIM ID133435