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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CBL (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID867
Official gene symbolCBL
Full nameCas-Br-M (murine) ecotropic retroviral transforming sequence
Aliases,C-CBL,CBL2,RNF55,
Gene summaryThe cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q23.3
Gene position119076990 - 119178859  Map Viewer
Gene orientationplus
Gene size101870 bp
Gene sequence
OMIM ID165360