| Entrez gene ID | | 8704 |
|
| Official gene symbol | | B4GALT2 |
|
| Full name | | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 |
|
| Aliases | | ,B4Gal-T2,B4Gal-T3,beta4Gal-T2, |
|
| Gene summary | | This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] |
|
| Location | | Chromosome: 1 Locus: 1p34-p33 |
|
| Gene position | | 44444866 - 44456840 Map Viewer |
|
| Gene orientation | | plus |
|
| Gene size | | 11975 bp |
|
| Gene sequence |
| |
|
| OMIM ID | | 604013 |
|
|
|
