Entrez gene ID | | 8717 |
Official gene symbol | | TRADD |
Full name | | TNFRSF1A-associated via death domain |
Aliases | | ,Hs.89862,MGC11078, |
Gene summary | | The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16q22 |
Gene position | | 67193812 - 67188088 Map Viewer |
Gene orientation | | minus |
Gene size | | 5725 bp |
Gene sequence |
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OMIM ID | | 603500 |
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